Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/5580
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dc.contributor.authorÖzçivici, Engin-
dc.contributor.authorZhang, Weidong-
dc.contributor.authorDonahue, Leah Rae-
dc.contributor.authorJudex, Stefan-
dc.date.accessioned2017-05-23T12:09:09Z
dc.date.available2017-05-23T12:09:09Z
dc.date.issued2014-07
dc.identifier.citationÖzçivici, E., Zhang, W., Donahue, L.R., and Judex, S. (2014). Quantitative trait loci that modulate trabecular bone's risk of failure during unloading and reloading. Bone, 64, 25-32. doi:10.1016/j.bone.2014.03.042en_US
dc.identifier.issn8756-3282
dc.identifier.issn8756-3282-
dc.identifier.urihttps://doi.org/10.1016/j.bone.2014.03.042
dc.identifier.urihttp://hdl.handle.net/11147/5580
dc.description.abstractGenetic makeup of an individual is a strong determinant of the morphologic and mechanical properties of bone. Here, in an effort to identify quantitative trait loci (QTLs) for changes in the simulated mechanical parameters of trabecular bone during altered mechanical demand, we subjected 352. second generation female adult (16. weeks old) BALBxC3H mice to 3. weeks of hindlimb unloading followed by 3. weeks of reambulation. Longitudinal in vivo microcomputed tomography (μCT) scans tracked trabecular changes in the distal femur. Tomographies were directly translated into finite element (FE) models and subjected to a uniaxial compression test. Apparent trabecular stiffness and components of the Von Mises (VM) stress distributions were computed for the distal metaphysis and associated with QTLs. At baseline, five QTLs explained 20% of the variation in trabecular peak stresses across the mouse population. During unloading, three QTLs accounted for 14% of the variability in peak stresses. During reambulation, one QTL accounted for 5% of the variability in peak stresses. QTLs were also identified for mechanically induced changes in stiffness, median stress values and skewness of stress distributions. There was little overlap between QTLs identified for baseline and QTLs for longitudinal changes in mechanical properties, suggesting that distinct genes may be responsible for the mechanical response of trabecular bone. Unloading related QTLs were also different from reambulation related QTLs. Further, QTLs identified here for mechanical properties differed from previously identified QTLs for trabecular morphology, perhaps revealing novel gene targets for reducing fracture risk in individuals exposed to unloading and for maximizing the recovery of trabecular bone's mechanical properties during reambulation.en_US
dc.description.sponsorshipNASA (NAG 9-1499--NNX08BA35G--NNX12AL25G)en_US
dc.language.isoenen_US
dc.publisherElsevier Ltd.en_US
dc.relation.ispartofBoneen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFinite element methoden_US
dc.subjectGenetic researchen_US
dc.subjectMechanical loadingen_US
dc.subjectStressen_US
dc.subjectQuantitative trait locien_US
dc.titleQuantitative trait loci that modulate trabecular bone's risk of failure during unloading and reloadingen_US
dc.typeArticleen_US
dc.authoridTR30296en_US
dc.institutionauthorÖzçivici, Engin-
dc.departmentIzmir Institute of Technology. Mechanical Engineeringen_US
dc.identifier.volume64en_US
dc.identifier.startpage25en_US
dc.identifier.endpage32en_US
dc.identifier.wosWOS:000337011500005en_US
dc.identifier.scopus2-s2.0-84904476695en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.bone.2014.03.042-
dc.identifier.pmid24698783en_US
dc.relation.doi10.1016/j.bone.2014.03.042en_US
dc.coverage.doi10.1016/j.bone.2014.03.042en_US
dc.identifier.scopusqualityQ1-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.grantfulltextopen-
item.openairetypeArticle-
item.languageiso639-1en-
crisitem.author.dept03.01. Department of Bioengineering-
Appears in Collections:Mechanical Engineering / Makina Mühendisliği
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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