Tensile adhesion of type I collagen to titanium alloy and calcium phosphate coated surfaces with different roughness values

Abstract

The purpose of total joint arthroplasty is to reduce pain and restore function. Its success depends on the formation of a new bone that stabilizes the prosthesis. The proposed solution for this important problem is to have bio-coated implant surfaces which are more conductive to bone growth. Additionally, collagen has long been used as a matrix for medical applications, because of its biocompatibility and adaptability. In this study, a test method for measuring the tensile adhesion strength of collagen to titanium alloy and calcium phosphate coated surfaces with different roughness values was developed, in order to evaluate how well the collagen adheres to the metallic and bio-coated surfaces. A precision motion system was used to stretch gels that were adherent to the plate surfaces. The tests were done in DMEM solution. The adhesive strength between the collagen gel and plate was significantly higher for calcium phosphate coated surfaces. Adhesive strength was highest in the sample with the highest roughness value.