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Title: Systematic tuning the hydrodynamic diameter of uniformed fluorescent silica nanoparticles
Authors: Durgun, Gülay
Ocakoğlu, Kasım
Özçelik, Serdar
Keywords: Fluorescent silica nanoparticles
Silica networks
Cell viability
PC3 cell lines
Issue Date: Aug-2011
Publisher: American Chemical Society
Source: Durgun, G., Ocakoğlu, K., Özçelik, S. (2011). Systematic tuning the hydrodynamic diameter of uniformed fluorescent silica nanoparticles. Journal of Physical Chemistry C, 115 (33), 16322–16332. doi:10.1021/jp204323d
Abstract: We report a facile method for systematic tuning the hydrodynamic diameter of uniformed fluorescent silica particles in the size range from 12 to 465 nm. Dynamic light scattering and electron microscopy studies demonstrate that the hydrodynamic size distribution of the silica particles is uniform. We show that the initial amounts of ethanol and ammonia are essential to tune the size of these particles. The hydrodynamic diameter of such a particle increases as the amount of ammonia is increased. On the other hand, an increase in the amount of ethanol leads to the formation of smaller particles. Higher initial amount of ethanol yield an increase in the concentration of ethoxide ions and a decrease in the concentration of hydroxide ions. Such control over the concentration of hydroxide ion, which is responsible for the formation of siloxane bonds, causes a controlled-growth of the silica particles, resulting in precise tuning the hydrodynamic size. We confirm that a linear relationship exists between size and brightness of particles, demonstrating that the amount of dye molecules in such particles can be regulated by the presented method. We prove that the silica network provides protection for dye molecules encapsulated in particles against solvents, fluorescence quenchers, and unfavorable pH of environments. Moreover, the fluorescent silica particles with the size of 12, 50 and 250 nm were found to not be cytotoxic against the epithelial cell lines of MCF7 and PC3 even when the dosage levels up to 1.0 mg/ml and incubation periods up to 72 hours were applied.
ISSN: 1932-7447
Appears in Collections:Chemistry / Kimya
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Sürdürülebilir Yeşil Kampüs Koleksiyonu / Sustainable Green Campus Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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