Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/4114
Title: Systematic tuning the hydrodynamic diameter of uniformed fluorescent silica nanoparticles
Authors: Durgun, Gülay
Ocakoğlu, Kasım
Özçelik, Serdar
Keywords: Fluorescent silica nanoparticles
Hydrodynamics
Silica networks
Cell viability
MCF7
PC3 cell lines
Issue Date: Aug-2011
Publisher: American Chemical Society
Source: Durgun, G., Ocakoğlu, K., Özçelik, S. (2011). Systematic tuning the hydrodynamic diameter of uniformed fluorescent silica nanoparticles. Journal of Physical Chemistry C, 115 (33), 16322–16332. doi:10.1021/jp204323d
Abstract: We report a facile method for systematic tuning the hydrodynamic diameter of uniformed fluorescent silica particles in the size range from 12 to 465 nm. Dynamic light scattering and electron microscopy studies demonstrate that the hydrodynamic size distribution of the silica particles is uniform. We show that the initial amounts of ethanol and ammonia are essential to tune the size of these particles. The hydrodynamic diameter of such a particle increases as the amount of ammonia is increased. On the other hand, an increase in the amount of ethanol leads to the formation of smaller particles. Higher initial amount of ethanol yield an increase in the concentration of ethoxide ions and a decrease in the concentration of hydroxide ions. Such control over the concentration of hydroxide ion, which is responsible for the formation of siloxane bonds, causes a controlled-growth of the silica particles, resulting in precise tuning the hydrodynamic size. We confirm that a linear relationship exists between size and brightness of particles, demonstrating that the amount of dye molecules in such particles can be regulated by the presented method. We prove that the silica network provides protection for dye molecules encapsulated in particles against solvents, fluorescence quenchers, and unfavorable pH of environments. Moreover, the fluorescent silica particles with the size of 12, 50 and 250 nm were found to not be cytotoxic against the epithelial cell lines of MCF7 and PC3 even when the dosage levels up to 1.0 mg/ml and incubation periods up to 72 hours were applied.
URI: http://dx.doi.org/10.1021/jp204323d
http://hdl.handle.net/11147/4114
ISSN: 1932-7447
1932-7455
Appears in Collections:Chemistry / Kimya
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Sürdürülebilir Yeşil Kampüs Koleksiyonu / Sustainable Green Campus Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Files in This Item:
File Description SizeFormat 
sozcelik silica.pdf2.33 MBAdobe PDFThumbnail
View/Open
Show full item record



CORE Recommender

SCOPUSTM   
Citations

16
checked on Feb 16, 2024

WEB OF SCIENCETM
Citations

16
checked on Jan 20, 2024

Page view(s)

158
checked on Feb 23, 2024

Download(s)

274
checked on Feb 23, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.