Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/1991
Title: Determination of benazepril HCl and hydrochlorothiazide in pharmaceutical preparations using UV-visible spectrophotometry and genetic multivariate calibration method
Authors: Özdemir, Durmuş
Dinç, Erdal
Özdemir, Durmuş
Keywords: Benazepril plus hydrochlorothiazide
Divitab
Genetic algorithms
Genetic regression
Multivariate calibration
Issue Date: Feb-2005
Publisher: Taiwan Food and Drug Administration
Source: Özdemir, D., and Dinç, E. (2005). Determination of benazepril HCl and hydrochlorothiazide in pharmaceutical preparations using UV-visible spectrophotometry and genetic multivariate calibration method. Journal of Food and Drug Analysis,13(4), 301-311.
Abstract: Simultaneous determination of binary mixtures of benazepril and hydrochlorothiazide in pharmaceutical tablets using UV-visible spectrophotometry, classical least squares (CLS) and three genetic algorithms (GA) based multivariate calibration methods was demonstrated. The three genetic multivariate calibration methods are Genetic Classical Least Squares (GCLS), Genetic Inverse Least Squares (GILS) and Genetic Regression (GR). The sample data set contains the UV- spectra of 28 synthetic mixtures of benazepril (12∼36 μg/mL) and hydrochlorothiazide (10∼22 μg/mL) and 16 tablets containing both compounds. The spectra cover the range from 210 to 360 nm in 0.1 mn intervals. Several calibration models were built with the four methods. The root mean square error of calibration (RMSEC) and validation (RMSEV) for the synthetic data were in the range of 0.19 and 0.34 μg/mL for all the genetic algorithm based methods. The root mean square error of Prediction (RMSEP) values for the tablets were in the range of 0.04∼0.20 mg/tablets. A comparison of genetic algorithm selected wavelengths for each component was also included.
URI: http://hdl.handle.net/11147/1991
ISSN: 1021-9498
1021-9498
Appears in Collections:Chemistry / Kimya
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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