Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/15308
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dc.contributor.authorKehr, Nermin Seda-
dc.date.accessioned2025-02-05T09:48:48Z-
dc.date.available2025-02-05T09:48:48Z-
dc.date.issued2025-
dc.identifier.issn1748-6041-
dc.identifier.issn1748-605X-
dc.identifier.urihttps://doi.org/10.1088/1748-605X/ada240-
dc.identifier.urihttps://hdl.handle.net/11147/15308-
dc.description.abstractInjectable nanocomposite hydrogels (NC hydrogels) have the potential to be used for minimally invasive local drug delivery. In particular, pH-sensitive injectable NC hydrogels can be used in cancer treatment to deliver high doses of anticancer drugs to the target site in cancer tissue without damaging healthy tissue. Recent studies have shown that in addition to stimuli-responsive delivery of anticancer drugs to cancer cells, oxygen delivery to the hypoxic environment of cancer tissue can lead to advanced effects, as hypoxia and an acidic pH are common characteristics of cancer tissue. However, few studies have investigated the effects of simultaneous administration of oxygen (O2) and pH-dependent anticancer drugs via injectable NC hydrogels on the viability of healthy and cancer cells under normoxic and hypoxic conditions. In this context, we describe the synthesis of injectable NC hydrogels composed of pH-responsive nanomaterials carrying oxygen and anticancer drugs. Our system provides sustained O2 release and pH-responsive sustained release of anticancer drugs for 15 and 30 d, respectively. Moreover, O2 delivery and/or simultaneous delivery of O2 and anticancer drug resulted in higher cell survival of healthy fibroblast cells than malignant Colo-818 cells under hypoxic conditions (1% O2) after 7 d of incubation.en_US
dc.description.sponsorshipIzmir Institute of Technologyen_US
dc.description.sponsorshipNermin Seda Kehr would like to thank Izmir Institute of Technology MAM and BIOMER Center for analytical measurements (SEM, DLS, zeta potential) and cell culture laboratory use.en_US
dc.language.isoenen_US
dc.publisherIop Publishing Ltden_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOxygen Deliveryen_US
dc.subjectAnticancer Drug Deliveryen_US
dc.subjectHypoxiaen_US
dc.subjectPh-Responsive Nanomaterialsen_US
dc.subjectInjectable Hydrogelen_US
dc.titleInjectable Nanocomposite Hydrogels With Co-Delivery of Oxygen and Anticancer Drugs for Higher Cell Viability of Healthy Cells Than Cancer Cells Under Normoxic and Hypoxic Conditionsen_US
dc.typeArticleen_US
dc.institutionauthorKehr, Nermin Seda-
dc.departmentİzmir Institute of Technologyen_US
dc.identifier.volume20en_US
dc.identifier.issue1en_US
dc.identifier.wosWOS:001390643200001-
dc.identifier.scopus2-s2.0-85214650273-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1088/1748-605X/ada240-
dc.identifier.pmid39706158-
dc.authorscopusid36129558600-
dc.identifier.wosqualityQ2-
dc.identifier.scopusqualityQ2-
dc.description.woscitationindexScience Citation Index Expanded-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
crisitem.author.dept04.01. Department of Chemistry-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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