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https://hdl.handle.net/11147/14884
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DC Field | Value | Language |
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dc.contributor.author | Can,G. | - |
dc.contributor.author | Cakir,Z. | - |
dc.contributor.author | Kartal,M. | - |
dc.contributor.author | Gunduz,U. | - |
dc.contributor.author | Baran,Y. | - |
dc.date.accessioned | 2024-10-25T23:21:46Z | - |
dc.date.available | 2024-10-25T23:21:46Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0250-7005 | - |
dc.identifier.uri | https://hdl.handle.net/11147/14884 | - |
dc.description.abstract | Aim: To examine the antiproliferative and apoptotic effects of resveratrol on imatinib-sensitive and imatinib-resistant K562 chronic myeloid leukemia cells. Materials and Methods: Antiproliferative effects of resveratrol were determined by the 3-Bis[2-methoxy-4-nitro-5-sulphophenyl]-2H-tetrazolium-5- carboxanilide inner salt (XTT) cell proliferation assay. Apoptotic effects of resveratrol on sensitive K562 and resistant K562/IMA-3 cells were determined through changes in caspase-3 activity, loss of mitochondrial membrane potential (MMP), and apoptosis by annexin V-(FITC). Results: The concentrations of resveratrol that inhibited cell growth by 50% ( IC50) were calculated as 85 and 122 μM for K562 and K562/IMA-3 cells, respectively. There were 1.91-, 7.42- and 14.73-fold increases in loss of MMP in K562 cells treated with 10, 50, and 100 μM resveratrol, respectively. The same concentrations of resveratrol resulted in 2.21-, 3.30- and 7.65-fold increases in loss of MMP in K562/IMA-3 cells. Caspase-3 activity increased 1.04-, 2.77- and 4.8-fold in K562 and 1.02-, 1.41- and 3.46-fold in K562/IMA- 3 cells in response to the same concentrations of resveratrol, respectively. Apoptosis was induced in 58.7%-and 43.3% of K562 and K562/IMA-3 cells, respectively, in response to 100 μM resveratrol. Conclusion: Taken together these results may suggest potential use of resveratrol in CML, as well as in patients with primary and/or acquired resistance to imatinib. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Anticancer Research | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | Chronic myeloid leukemia | en_US |
dc.subject | Drug resistance | en_US |
dc.subject | Imatinib resistance | en_US |
dc.subject | K562 CML cells | en_US |
dc.subject | Resveratrol | en_US |
dc.title | Apoptotic effects of resveratrol, a grape polyphenol, onimatinib-sensitive and resistant K562 chronic myeloid leukemia cells | en_US |
dc.type | Article | en_US |
dc.department | Izmir Institute of Technology | en_US |
dc.identifier.volume | 32 | en_US |
dc.identifier.issue | 7 | en_US |
dc.identifier.startpage | 2373 | en_US |
dc.identifier.endpage | 2678 | en_US |
dc.identifier.scopus | 2-s2.0-84865679765 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | [SCOPUS-DOI-BELIRLENECEK-41] | - |
dc.identifier.pmid | 22753725 | - |
dc.authorscopusid | 57205656780 | - |
dc.authorscopusid | 35791683300 | - |
dc.authorscopusid | 37050733400 | - |
dc.authorscopusid | 26643388500 | - |
dc.authorscopusid | 9636164400 | - |
dc.identifier.wosquality | Q4 | - |
dc.identifier.scopusquality | Q3 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairetype | Article | - |
item.fulltext | No Fulltext | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection |
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