Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/14866
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dc.contributor.authorBaykal, Seda-
dc.contributor.authorYuce, Zeynep-
dc.contributor.authorOzhan, Gunes-
dc.date.accessioned2024-10-25T23:18:51Z-
dc.date.available2024-10-25T23:18:51Z-
dc.date.issued2024-
dc.identifier.issn1582-1838-
dc.identifier.issn1582-4934-
dc.identifier.urihttps://doi.org/10.1111/jcmm.70105-
dc.identifier.urihttps://hdl.handle.net/11147/14866-
dc.descriptionBaykal, Seda/0000-0001-8654-5332en_US
dc.description.abstractUnderstanding the mechanisms by which cancer cells switch between different adaptive states and evade therapeutic interventions is essential for clinical management. In this study, the in vivo cellular dynamics of a new chronic myeloid leukaemia cell line displaying altered phenotype and resistance to tyrosine kinase inhibitors were investigated in correlation with their parental cells for invasiveness/metastasis, angiogenic potential and population kinetics. We showed that the cells exhibiting drug resistance and plastic phenotype possess an increased capacity for invasion compared to their parental cells, that exposure to imatinib mesylate has the potential to enhance cellular motility and that in a leukaemic cell population, even a minority of plastic cells exhibit improved migratory ability. Furthermore, we show that these plastic cells have angiogenic and extravasation potential. The present study provides significant insights into the cellular dynamics displayed by a TKI-resistant, phenotypically plastic CML cell line, using a zebrafish (Danio rerio) xenograft model.en_US
dc.description.sponsorshipTechnological Research Council of Turkiye (TUBIdot;TAK) [118C459]en_US
dc.description.sponsorshipThe Scientific and Technological Research Council of Turkiye (TUB & Idot;TAK), Grant/Award Number: 118C459en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcell motilityen_US
dc.subjectcell plasticityen_US
dc.subjectCMLen_US
dc.subjectinvasionen_US
dc.subjectK562en_US
dc.subjectresistanceen_US
dc.titlePhenotypically plastic drug-resistant chronic myeloid leukaemia cell line displays enhanced cellular dynamics in a zebrafish xenograft modelen_US
dc.typeArticleen_US
dc.authoridBaykal, Seda/0000-0001-8654-5332-
dc.departmentIzmir Institute of Technologyen_US
dc.identifier.volume28en_US
dc.identifier.issue19en_US
dc.identifier.wosWOS:001329935800001-
dc.identifier.scopus2-s2.0-85206049176-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1111/jcmm.70105-
dc.identifier.pmid39392217-
dc.authorscopusid57216327790-
dc.authorscopusid6504184333-
dc.authorscopusid56015666900-
dc.identifier.wosqualityQ2-
dc.identifier.scopusqualityQ1-
dc.description.woscitationindexScience Citation Index Expanded-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairetypeArticle-
item.fulltextNo Fulltext-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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