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https://hdl.handle.net/11147/14639
Title: | A new insight into the pathway behind spontaneous recurrent pregnancy loss: decreased CYR61 gene expression | Authors: | Firatligil, Fahri Burcin Yildirir, Burcu Firatligil Yalcin-Ozuysal, Ozden |
Keywords: | Cytogenetics Miscarriage Molecular genetics |
Publisher: | Assoc Medica Brasileira | Abstract: | OBJECTIVE: Investigating the potential role of CYR61 in recurrent pregnancy loss is critical for developing diagnostic approaches and treatments for recurrent pregnancy loss. METHODS: In this prospective case-control study, we have investigated the expression patterns of CYR61 in blood samples from participants with recurrent pregnancy loss in their medical history and control group (n=20 vs n=10). Peripheral blood mononuclear cells from study and control groups were isolated and the expression patterns of the CYR61 gene were determined by real-time semi-quantitative reverse transcriptase PCR. RESULTS: A significant decrease in CYR61 gene expression was demonstrated in patients with two or more clinically recognized miscarriages compared with patients without miscarriages or with a history of miscarriage (p<0.01), which may make the CYR61 gene a potential candidate for predicting the risk of recurrent pregnancy loss. DISCUSSION: This study provides a basis for a detailed investigation of candidate biomarkers and molecular players involved in the development of recurrent pregnancy loss and for the development of potential treatment approaches to prevent recurrent pregnancy loss. | URI: | https://doi.org/10.1590/1806-9282.20231673 https://hdl.handle.net/11147/14639 |
ISSN: | 0104-4230 1806-9282 |
Appears in Collections: | Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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