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https://hdl.handle.net/11147/13201
Title: | Neo-Clerodanes From Teucrium Divaricatum Subsp. Divaricatum and Their Biological Activity Assessment |
Authors: | Aydoğan, Fadime Ali, Zülfiqar Zülfiqar, Fazila Karaalp, Canan Khan, Ikhlas A. Bedir, Erdal |
Keywords: | Antimicrobial iNOS Lamiaceae |
Publisher: | Elsevier |
Abstract: | Fifteen neo-clerodane diterpenoids (1–15), including two undescribed glycosides, teudivaricosides A (1) and B (2), together with a known iridoid glycoside (16) and a phenylpropanoid glycoside (17) from the whole plant of Teucrium divaricatum subsp. divaricatum were isolated. Their structures were determined by spectral data analysis including 1D and 2D NMR and HRESIMS. Neo-clerodane diterpenoids were evaluated for their anti-inflammatory, and antimicrobial activities. None of them showed significant antimicrobial activity against various bacterial and fungal strains (up to 20 µg/mL). All tested compounds were inactive up to the highest tested concentration of 50 µM on iNOS inhibitory activity. |
URI: | https://doi.org/10.1016/j.phytol.2023.01.010 https://hdl.handle.net/11147/13201 |
ISSN: | 1874-3900 |
Appears in Collections: | Bioengineering / Biyomühendislik Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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