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https://hdl.handle.net/11147/13201| Title: | neo-Clerodanes from Teucrium divaricatum subsp. divaricatum and their biological activity assessment | Authors: | Aydoğan, Fadime Ali, Zülfiqar Zülfiqar, Fazila Karaalp, Canan Khan, Ikhlas A. Bedir, Erdal Dicle Üniversitesi University of Mississippi University of Mississippi Ege Üniversitesi University of Mississippi 01. Izmir Institute of Technology |
Keywords: | Antimicrobial iNOS Lamiaceae |
Issue Date: | Apr-2023 | Publisher: | Elsevier | Abstract: | Fifteen neo-clerodane diterpenoids (1–15), including two undescribed glycosides, teudivaricosides A (1) and B (2), together with a known iridoid glycoside (16) and a phenylpropanoid glycoside (17) from the whole plant of Teucrium divaricatum subsp. divaricatum were isolated. Their structures were determined by spectral data analysis including 1D and 2D NMR and HRESIMS. Neo-clerodane diterpenoids were evaluated for their anti-inflammatory, and antimicrobial activities. None of them showed significant antimicrobial activity against various bacterial and fungal strains (up to 20 µg/mL). All tested compounds were inactive up to the highest tested concentration of 50 µM on iNOS inhibitory activity. | URI: | https://doi.org/10.1016/j.phytol.2023.01.010 https://hdl.handle.net/11147/13201 |
| Appears in Collections: | Bioengineering / Biyomühendislik Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| 13201.pdf Until 2025-07-01 | Article | 1 MB | Adobe PDF | View/Open Request a copy |
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