Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/12402
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dc.contributor.authorGüngör, Serdaren_US
dc.contributor.authorBulduk, Ibrahimen_US
dc.contributor.authorAydın, Beyza Sultanen_US
dc.contributor.authorİlikçi Sağkan, Rahşanen_US
dc.date.accessioned2022-08-24T07:56:29Z-
dc.date.available2022-08-24T07:56:29Z-
dc.date.issued2022-09-
dc.identifier.issn1233-2356-
dc.identifier.urihttp://dx.doi.org/10.1556/1326.2021.00925-
dc.identifier.urihttps://hdl.handle.net/11147/12402-
dc.description.abstractOseltamivir is an antiviral drug and is used in the treatment of all influenza viruses. It is the most effective antiviral option against all influenza viruses that can infect humans. UV and LC methods have been developed and validated according to ICH guidelines for various parameters like selectivity, linearity, accuracy, precision, LOD and LOQ, robustness for the quantitative determination of oseltamivir in pharmaceutical formulations. LC method has been performed using reverse phase technique on a C-18 column with a mobile phase consisting of 20 mM potassium dihydrogen phosphate solution and acetonitrile (60:40, v/v) at 25 8C. The mobile phase flow rate was 1.2 mL min-1. For the determination of oseltamivir, UV spectrum has been recorded between 200 and 800 nm using methanol as solvent and the wavelength of 215 nm has been selected. Both methods have demonstrated good linearity, precision and recovery. No spectral and chromatographic interferences from the capsule excipients were found in UV and LC methods. In both methods, correlation coefficients were greater than 0.999 within a concentration range of 10???60 mg mL-1 using UV and LC. Intra-day and inter-day precision with low relative standard deviation values were observed. The accuracy of these methods was within the range 99.85???100.17% for LC and from 99.26 to 100.70% for UV. Therefore UV and LC methods gave the most reliable outcomes for the determination of oseltamivir in pharmaceutical formulation.en_US
dc.language.isoenen_US
dc.publisherAkademiai Kiadoen_US
dc.relation.ispartofActa Chromatographicaen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOseltamiviren_US
dc.subjectCOVID-19en_US
dc.subjectUltravioleten_US
dc.subjectLC methodsen_US
dc.titleA comparative study of HPLC and UV spectrophotometric methods for oseltamivir quantification in pharmaceutical formulationsen_US
dc.typeArticleen_US
dc.institutionauthorAydın, Beyza Sultanen_US
dc.departmentİzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.wosWOS:000810400500007en_US
dc.identifier.scopus2-s2.0-85137825432en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1556/1326.2021.00925-
dc.contributor.affiliationUşak Üniversitesien_US
dc.contributor.affiliationUşak Üniversitesien_US
dc.contributor.affiliationIzmir Institute of Technologyen_US
dc.contributor.affiliationUşak Üniversitesien_US
dc.relation.issn1233-2356en_US
dc.description.volume34en_US
dc.description.issue3en_US
dc.description.startpage258en_US
dc.description.endpage266en_US
dc.identifier.wosqualityQ3-
dc.identifier.scopusqualityQ2-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.openairetypeArticle-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextopen-
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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