Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/12341
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dc.contributor.authorÖzdemir, Özgün Öykü-
dc.contributor.authorSoyer, Ferda-
dc.date.accessioned2022-08-15T18:23:28Z-
dc.date.available2022-08-15T18:23:28Z-
dc.date.issued2021-
dc.identifier.issn2287-237X-
dc.identifier.issn2287-2388-
dc.identifier.urihttps://doi.org/10.12989/anr.2021.11.3.227-
dc.identifier.urihttps://hdl.handle.net/11147/12341-
dc.description.abstractEncapsulation of bioactive compounds (e.g., phenolic acids) into nanoparticles is a well-received technique in the searching for new antimicrobial agents against multidrug-resistant pathogens. Encapsulation can be a good technique to maintain the stability of phenolic acids against environmental conditions. In this study, 3-hydroxyphenylacetic acid (3-HPAA) was encapsulated into alginate-chitosan nanoparticles with the ion gelation technique. The characterization of loaded and unloaded nanoparticles was performed via dynamic light scattering, Fourier transform infrared spectroscopy, and scanning electron microscopy. According to the results, 3-HPAA loaded nanoparticles have spherical shapes with a diameter range of 40-80 nm and an average hydrodynamic diameter of 361.0 +/- 69.8 nm. The loading of 3-HPAA was successfully achieved based on the Fourier transform infrared spectra and encapsulation percentage studies. The antimicrobial effect of the nanoparticles in solution forms was tested on P. aeruginosa, S. epidermidis, MRSA, and MSSA. The results demonstrated that the 3-HPAA loaded alginate chitosan nanoparticle solution showed elevated antimicrobial effect due to the pH change by treatment with 1% acetic acid, and it displayed bacteriocidal effects in a strain-specific and dose-dependent manner. Therefore, the 3-HPAA loaded alginate chitosan nanoparticle solution was produced successfully with the bacteriocidal effect against serious pathogenic bacteria.en_US
dc.description.sponsorshipWe would like to thank Izmir Institute of Technology, Biotechnology and Bioengineering Research and Application Center and Izmir Institute of Technology, Center for Materials Research. This work was funded by Izmir Institute of Technology Research Fund by Project #2014IYTE22.en_US
dc.language.isoenen_US
dc.publisherTechno Pressen_US
dc.relationEscherichia coli O157:H7’nin 3-hidroksifenilasetik asit varlığında dış zar protein profilinin analizi-
dc.relation.ispartofAdvances in Nano Researchen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject3-hydroxyphenylacetic aciden_US
dc.subjectPseudomonas aeruginosaen_US
dc.subjectPathogenic bacteriaen_US
dc.titleSynthesis, characterization, and antimicrobial activities of 3-HPAA-Alg-Chi nanoparticlesen_US
dc.typeArticleen_US
dc.departmentİzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume11en_US
dc.identifier.issue3en_US
dc.identifier.startpage227en_US
dc.identifier.endpage237en_US
dc.identifier.wosWOS:000731574600001en_US
dc.identifier.scopus2-s2.0-85123572189en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.12989/anr.2021.11.3.227-
dc.relation.grantno2014İYTE22-
dc.identifier.wosqualityQ2-
dc.identifier.scopusqualityQ2-
item.grantfulltextopen-
item.openairetypeArticle-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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