Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/12179
Title: Development of liposomal formulations of the eggplant glycoalkaloids solasonine and solamargine
Authors: Tatlıdil, Engin
Gürbüz, Nergiz
Doğanlar, Sami
Frary, Anne
Izmir Institute of Technology
Izmir Institute of Technology
Izmir Institute of Technology
Izmir Institute of Technology
Keywords: Biomacromolecules
Genus solanum
Liposomes
Issue Date: Apr-2022
Publisher: Elsevier
Abstract: The eggplant glycoalkaloids solasonine and solamargine are efficient biomacromolecules against skin diseases but are water-insoluble which results in inefficient treatment due to inadequate transdermal delivery. To address this problem, several liposomal formulations were prepared and evaluated for parameters including lecithin type, hydration temperature, and pH. The optimal formula with high physical and chemical stability included the lecithin Phospholipon 80H hydrated with 10 mM NaCl (pH 5.5). Solasonine - solamargine loaded liposomes were tested for their physical and chemical stability and drug leakage over a three-month period. Furthermore, the drug release profile of the loaded liposomes was evaluated with different release media. The glycoalkaloids and their liposomal formulations were assessed for their biological activity in culture using HaCaT and SCC-25 cell lines. This work resulted in a biologically effective liposomal formulation that was stable (size <220 nm, PDI [removed]80%) for at least three months.
URI: https://doi.org/10.1016/j.jddst.2022.103194
https://hdl.handle.net/11147/12179
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Files in This Item:
File Description SizeFormat 
1-s2.0-S1773224722001034-main.pdf
  Until 2025-07-01
Article4.04 MBAdobe PDFView/Open    Request a copy
Show full item record

CORE Recommender

Page view(s)

18,992
checked on Sep 26, 2022

Download(s)

2
checked on Sep 26, 2022

Google ScholarTM

Check

Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.