Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/12085
Title: Characterization of water solubility and binding of spin labeled drugs in the presence of albumin nanoparticles and proteins by electron paramagnetic resonance spectroscopy
Authors: Sözer, Sümeyra Çiğdem
Akdoğan, Yaşar
Izmir Institute of Technology
Izmir Institute of Technology
Keywords: Drug binding
Albumin nanoparticles
Drug solubility
EPR spectroscopy
Issue Date: Feb-2022
Publisher: Wiley-Blackwell
Abstract: Electron paramagnetic resonance (EPR) spectroscopy is an advantageous technique to monitor solubility of drugs in an aqueous solution. In the presence of a drug carrier, the bound and unbound drug fractions can be determined in the same sample simultaneously. To enhance the solubility of hydrophobic drugs, a transporter protein of bovine serum albumin (BSA) can be used directly or in the form of nanoparticle. Moreover, a cationic BSA can be used to enhance anionic drug loading. Here, drugs with different water solubility, salicylic acid (high), ibuprofen (low) and chlorambucil (none) were spin labeled and studied with EPR spectroscopy. Remarkably, it has been shown that albumin nanoparticles are much more effective than albumin proteins in dissolving hydrophobic drugs in water. Furthermore, different drug loading methods were compared, and different from other techniques drug release can be monitored directly from the NPs pellet dissolution by EPR spectroscopy.
Description: This work was financially supported by Scientific and Technological Research Council of Turkey (TUBITAK) via 1001 Program under grant 118Z341 and 1002 Program under grant 119Z136.This work was financially supported by Scientific and Technological Research Council of Turkey (TUBITAK) via 1001 Program under grant 118Z341 and 1002 Program under grant 119Z136.
URI: https://doi.org/10.1002/slct.202103890
https://hdl.handle.net/11147/12085
Appears in Collections:Materials Science and Engineering / Malzeme Bilimi ve Mühendisliği
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

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