Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/12060
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dc.contributor.authorYılmaz, Asu Fergünen_US
dc.contributor.authorSaydam, Gürayen_US
dc.contributor.authorŞahin, Fahrien_US
dc.contributor.authorBaran, Yusufen_US
dc.date.accessioned2022-04-20T10:06:44Z-
dc.date.available2022-04-20T10:06:44Z-
dc.date.issued2013-
dc.identifier.urihttps://hdl.handle.net/11147/12060-
dc.description.abstractGranulocytic sarcoma also called myeloid sarcoma is an extramedullary tumor of immature granulocytic cells. It is a rare entity, and mostly accompanied by acute myeloid leukemia. It is observed during the course of myeloproliferative disorders especially in chronic myeloid leukemia and myelodysplastic syndromes. In some rare circumstances, it is detected before clinical signs of leukemia or other diseases. When the bone marrow biopsy reveals no other hematologic malignancies, the granulocytic sarcoma is described as nonleukemic, primary or isolated. It is observed at any part of the body but the most common locations are soft tissues, bone, peritoneum and lymph nodes. Presenting signs or symptoms are mainly due to mass effect of the tumor and dysfunction of the organ, or the tissue that is affected. The diagnosis is performed by biopsy of the tumor. The tumor consists of immature granulocytic cells, which could be documented by H&E, immunohistochemistry, and flow cytometric methods. Fluorescence in-situ hybridization and molecular analysis are also performed. The optimal time and type of treatment is not clear. Surgery could be an option especially for tumors, which cause organ dysfunction and/or obstruction. Systemic treatment should be considered in all patients because without systemic treatment, relapses and progression to acute myeloid leukemia is the ultimate fate of the disease in many cases. Cytarabine-containing remission-induction chemotherapies have been the most applied therapeutic strategies, but it is not clear whether the consolidation therapies are required or not, and what kind of regimens are appropriate. The role of hematopoietic stem cell transplantation (HSC) as a consolidation regimen is not clear, but, after the relapse of the disease with or without bone marrow involvement, HSC transplantation should be considered in suitable patients after the reinduction performed by AML chemotherapies. There is only limited data about the role of radiotherapy in these patients. It could be used in patients with relapsed disease, organ dysfunction which should be quickly relieved and inadequate response to chemotherapy. The effect of radiotherapy on overall survival is not known. New prospective studies and clinical trials are needed to generate guidelines for the treatment of primary granulocytic sarcomas.en_US
dc.language.isoenen_US
dc.publishere-Century Publishing Corporationen_US
dc.relation.ispartofAmerican Journal of Blood Researchen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGranulocytic sarcomaen_US
dc.subjectTreatmenten_US
dc.subjectChemotherapyen_US
dc.subjectLeukemiaen_US
dc.titleGranulocytic sarcoma: a systematic reviewen_US
dc.typeArticleen_US
dc.institutionauthorBaran, Yusufen_US
dc.departmentİzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.wosWOS:000214940800001en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid24396704-
dc.contributor.affiliationEge Üniversitesien_US
dc.contributor.affiliationEge Üniversitesien_US
dc.contributor.affiliationEge Üniversitesien_US
dc.contributor.affiliation01. Izmir Institute of Technologyen_US
dc.relation.issn2160-1992en_US
dc.description.volume3en_US
dc.description.issue4en_US
dc.description.startpage265en_US
dc.description.endpage270en_US
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.fulltextWith Fulltext-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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