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Title: Noncoding RNAs in apoptosis: identification and function
Authors: Tüncel, Özge
Kara, Merve
Yaylak, Bilge
Erdoğan, İpek
Akgül, Bünyamin
Izmir Institute of Technology
Izmir Institute of Technology
Izmir Institute of Technology
Izmir Institute of Technology
Izmir Institute of Technology
Keywords: Apoptosis
Noncoding RNA
Circular RNAs
Issue Date: 2022
Publisher: TÜBİTAK
Abstract: Apoptosis is a vital cellular process that is critical for the maintenance of homeostasis in health and disease. The derailment of apoptotic mechanisms has severe consequences such as abnormal development, cancer, and neurodegenerative diseases. Thus, there exist complex regulatory mechanisms in eukaryotes to preserve the balance between cell growth and cell death. Initially, protein coding genes were prioritized in the search for such regulatory macromolecules involved in the regulation of apoptosis. However, recent genome annotations and transcriptomics studies have uncovered a plethora of regulatory noncoding RNAs that have the ability to modulate not only apoptosis but also many other biochemical processes in eukaryotes. In this review article, we will cover a brief summary of apoptosis and detection methods followed by an extensive discussion on microRNAs, circular RNAs, and long noncoding RNAs in apoptosis.
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
TR Dizin İndeksli Yayınlar / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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