Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/11915
Full metadata record
DC FieldValueLanguage
dc.contributor.authorKeman, Denizen_US
dc.contributor.authorSoyer, Ferdaen_US
dc.date.accessioned2022-01-07T09:14:10Z-
dc.date.available2022-01-07T09:14:10Z-
dc.date.issued2021-08-
dc.identifier.urihttps://doi.org/10.2174/1570164617999200928213909-
dc.identifier.urihttps://hdl.handle.net/11147/11915-
dc.description.abstractBackground: The ability of Staphylococcus aureus to cause severe infections and the difficulty of the treatments due to the multiple antibiotic resistance make this bacterium a lifethreatening human pathogen. This situation necessitates the exploration of novel antimicrobial compounds with known targets on bacteria. Phenolic acids naturally produced in plants as secondary metabolites are good candidates for being alternative antimicrobials for antibiotic-resistant bacteria. Objective: Investigation of protein profile of Methicillin-Resistant S. Aureus (MRSA) in the presence of subinhibitory concentrations of phenolic acids. Methods: MRSA was subjected to subinhibitory concentrations of Vanillic Acid (VA) and 2-Hydroxycinnamic Acid (2-HCA), separately, and the proteomic analyses were carried out by using liquid chromatography coupled to mass spectrometry. Results: Both phenolic acids elicited identification of differently expressed proteins that have roles in DNA replication, repair, RNA processing and transcription, protein synthesis, maintenance of cell homeostasis, several metabolic reactions in energy, carbohydrate and lipid metabolisms and also proteins related with the virulence and the pathogenicity of MRSA when compared with the control group. The numbers of the proteins identified were 444, 375, and 426 for control, VA-treated MRSA, and 2-HCA-treated MRSA, respectively, from which 256 were shared. While VA treatment resulted in 149 unidentified MRSA proteins produced in control, 2-HCA treatment resulted in 126 unidentified proteins. Data are available via ProteomeXchange with identifier PXD016922. Conclusion: The results obtained from this study might indicate the potential targets on bacteria and the effective use of phenolic acids in the battle with antibiotic-resistant pathogens.en_US
dc.language.isoenen_US
dc.publisherBentham Science Publishersen_US
dc.relation.ispartofCurrent Proteomicsen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subject2-hydroxycinnamic aciden_US
dc.subjectProteomicsen_US
dc.subjectStaphylococcus aureusen_US
dc.subjectVanillic aciden_US
dc.subjectMRSAen_US
dc.titleComparative proteome profiles of methicillin-resistant staphylococcus aureus in response to vanillic acid and 2-hydroxycinnamic aciden_US
dc.typeArticleen_US
dc.authorid0000-0003-2291-2257en_US
dc.authorid0000-0001-8307-1258en_US
dc.institutionauthorKeman, Denizen_US
dc.institutionauthorSoyer, Ferdaen_US
dc.departmentİzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volumeWOS:000685511300009-
dc.identifier.wosWOS:000685511300009en_US
dc.identifier.scopus2-s2.0-85121029279en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.2174/1570164617999200928213909-
dc.contributor.affiliationIzmir Institute of Technologyen_US
dc.relation.issn1570-1646en_US
dc.description.volume18en_US
dc.description.issue4en_US
dc.description.startpage519en_US
dc.description.endpage535en_US
dc.identifier.wosqualityQ4-
item.languageiso639-1en-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.dept01. Izmir Institute of Technology-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Show simple item record



CORE Recommender

Page view(s)

46,028
checked on Mar 4, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.