Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/11913
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dc.contributor.authorGezer, Emreen_US
dc.contributor.authorÜner, Göklemen_US
dc.contributor.authorKüçüksolak, Melisen_US
dc.contributor.authorKurt, Mustafa Ünveren_US
dc.contributor.authorDoğan, Gamzeen_US
dc.contributor.authorBallar Kırmızıbayrak, Peteken_US
dc.contributor.authorBedir, Erdalen_US
dc.date.accessioned2022-01-06T13:10:18Z-
dc.date.available2022-01-06T13:10:18Z-
dc.date.issued2022-03-
dc.identifier.urihttps://doi.org/10.1016/j.phytochem.2021.113038-
dc.identifier.urihttps://hdl.handle.net/11147/11913-
dc.description.abstractPolyether ionophores represent a large group of naturally occurring compounds mainly produced by Streptomyces species. With previously proven varieties of bioactivity including antibacterial, antifungal, antiparasitic, antiviral and anti-tumor effects, the discovery of undescribed polyethers leading to development of efficient therapeutics has become important. As part of our research on polyether-rich Streptomyces cacaoi, we previously performed modification studies on fermentation conditions to induce synthesis of specialized metabolites. Here, we report four undescribed and nine known polyether compounds from S. cacaoi grown in optimized conditions. Antimicrobial activity assays revealed that four compounds, including the undescribed (6), showed strong inhibitory effects over both Bacillus subtilis and methicillin-resistant Staphylococcus aureus (MRSA) growth. Additionally, K41-A and its C15-demethoxy derivative exhibited significant cytotoxicity. These results signified that selectivity of C15-demethoxy K41-A towards cancer cells was higher than K41-A, which prompted us to conduct mechanistic experiments. These studies showed that this uninvestigated compound acts as a multitarget compound by inhibiting autophagic flux, inducing reactive oxygen species formation, abolishing proteasome activity, and stimulating ER stress. Consequently, the optimized fermentation conditions of S. cacaoi led to the isolation of undescribed and known polyethers displaying promising activities.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofPhytochemistryen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectActinobacteriaen_US
dc.subjectAutophagyen_US
dc.subjectPolyether ionophoresen_US
dc.subjectStreptomyces cacaoien_US
dc.subjectStreptomycetaceaeen_US
dc.titleUndescribed polyether ionophores from Streptomyces cacaoi and their antibacterial and antiproliferative activitiesen_US
dc.typeArticleen_US
dc.authorid0000-0001-9721-7297en_US
dc.authorid0000-0003-1619-4850en_US
dc.authorid0000-0003-1262-063Xen_US
dc.institutionauthorGezer, Emreen_US
dc.institutionauthorÜner, Göklemen_US
dc.institutionauthorKüçüksolak, Melisen_US
dc.institutionauthorKurt, Mustafa Ünveren_US
dc.institutionauthorDoğan, Gamzeen_US
dc.institutionauthorBedir, Erdalen_US
dc.departmentİzmir Institute of Technology. Bioengineeringen_US
dc.identifier.wosWOS:000761012300008en_US
dc.identifier.scopus2-s2.0-85120932427en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.phytochem.2021.113038-
dc.contributor.affiliation01. Izmir Institute of Technologyen_US
dc.contributor.affiliation01. Izmir Institute of Technologyen_US
dc.contributor.affiliation01. Izmir Institute of Technologyen_US
dc.contributor.affiliation01. Izmir Institute of Technologyen_US
dc.contributor.affiliation01. Izmir Institute of Technologyen_US
dc.contributor.affiliationEge Üniversitesien_US
dc.contributor.affiliation01. Izmir Institute of Technologyen_US
dc.description.volume195en_US
local.message.claim2022-06-08T12:09:30.891+0300|||rp02870|||submit_approve|||dc_contributor_author|||None*
dc.identifier.scopusqualityQ1-
item.fulltextWith Fulltext-
item.openairetypeArticle-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextembargo_20260101-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.dept01. Izmir Institute of Technology-
crisitem.author.dept01. Izmir Institute of Technology-
crisitem.author.dept03.01. Department of Bioengineering-
crisitem.author.dept03.01. Department of Bioengineering-
crisitem.author.dept03.01. Department of Bioengineering-
Appears in Collections:Bioengineering / Biyomühendislik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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