Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/11209
Full metadata record
DC FieldValueLanguage
dc.contributor.authorİçen, Mehmet Sinaen_US
dc.contributor.authorGürbüz, İlhanen_US
dc.contributor.authorBedir, Erdalen_US
dc.contributor.authorGünbatan, Tuğbaen_US
dc.contributor.authorDemirci, Fatihen_US
dc.date.accessioned2021-11-06T09:23:32Z-
dc.date.available2021-11-06T09:23:32Z-
dc.date.issued2021-
dc.identifier.issn0254-6299-
dc.identifier.urihttp://doi.org/10.1016/j.sajb.2021.04.030-
dc.identifier.urihttps://hdl.handle.net/11147/11209-
dc.description.abstractSalvia palaestina aqueous and methanol extracts were prepared from the aerial parts, which were evaluated for the in vitro anti-inflammatory properties using the lipoxygenase (LO) enzyme inhibition assay. While the aqueous extract showed no activity at test concentrations, a significant (p < 0.001) lipoxygenase inhibition was detected for the methanol extract with 29% inhibition. Activity guided fractionation was carried out on the methanol extract via liquid-liquid partitioning using n-hexane, dichloromethane, ethyl acetate, and n-butanol. The ethyl acetate fraction showed statistically the best inhibition among the sub-fractions with 70% inhibition (p < 0.0001). The compounds responsible for the activity were purified, and their structures were established as rosmarinic acid, and methyl rosmarinate by spectroscopic methods. IC50 values of rosmarinic acid, and methyl rosmarinate were calculated as 0.21 and 0.02 ?M, respectively. In conclusion, the in vitro anti-inflammatory potential of S. palaestina was associated to rosmarinic acid, and methyl rosmarinate, for the first time to the best of our knowledge. © 2021 SAABen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofSouth African Journal of Botanyen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectActivity-guided fractionationen_US
dc.subjectAnti-inflammatory activityen_US
dc.subjectLipoxygenaseen_US
dc.subjectRosmarinateen_US
dc.subjectSalvia palaestinaen_US
dc.titleIsolation of rosmarinic acid and methyl rosmarinate as lipoxygenase inhibitors from Salvia palaestina Benth. by activity-guided fractionationen_US
dc.typeArticleen_US
dc.institutionauthorBedir, Erdal-
dc.identifier.volume141en_US
dc.identifier.startpage177en_US
dc.identifier.endpage182en_US
dc.identifier.wosWOS:000752149500021en_US
dc.identifier.scopus2-s2.0-85106871246en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.sajb.2021.04.030-
dc.identifier.wosqualityQ2-
dc.identifier.scopusqualityQ2-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.fulltextWith Fulltext-
crisitem.author.dept03.01. Department of Bioengineering-
Appears in Collections:Bioengineering / Biyomühendislik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Files in This Item:
File SizeFormat 
1-s2.0-S0254629921001642-main.pdf746.76 kBAdobe PDFView/Open
Show simple item record



CORE Recommender

SCOPUSTM   
Citations

7
checked on Jun 21, 2024

WEB OF SCIENCETM
Citations

5
checked on Mar 16, 2024

Page view(s)

572
checked on Jun 24, 2024

Download(s)

44
checked on Jun 24, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.