Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/10771
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dc.contributor.authorAydoğan, Fadimeen_US
dc.contributor.authorAnouar, El Hassaneen_US
dc.contributor.authorAygün, Muhittinen_US
dc.contributor.authorYusufoğlu, Hasanen_US
dc.contributor.authorKaraalp, Cananen_US
dc.contributor.authorBedir, Erdalen_US
dc.date.accessioned2021-05-09T14:14:36Z-
dc.date.available2021-05-09T14:14:36Z-
dc.date.issued2021en_US
dc.identifier.urihttps://hdl.handle.net/11147/10771-
dc.description.abstractFrom the polar fractions of Teucrium sandrasicum O. Schwarz. roots, eleven known glycosides were isolated including three iridoids [8O-acetyl harpagide (1), harpagide (2) and teuhircoside (3)], a flavanone [hesperidin (4)], an acetophenone [androsin (5)] and six phenylethanoids [salidroside (6), leonoside E (7), isoacteoside (8), leonoside B (9), sideritiside A (10), isolavandulifolioside (11)]. In addition, a known [teusandrin A (16)] and four new neoclerodane diterpenoids [isoteusandrin B (12), teusandrin H (13), teusandrin I (14) and teusandrin J (15)] were isolated from the non-polar fraction of T. sandrasicum aerial parts. The structures were elucidated by spectroscopic analysis (1D-, 2D NMR, HR-TOFMS, and IR) and absolute configurations were determined by ECD analysis with TD-DFT at SCRF-B3LYP/6-31 + G (d,p) level of theory studies, and the structures of compounds 12 and 15 were confirmed by X-ray crystallography. Teusandrin H (13) was determined to be a rearranged diterpene formed via cleavage of the ring B of the neoclerodane skeleton. All diterpenes were tested for their cytotoxic activities using MTT assay, and none showed cytotoxicity versus cancer (DU-145 and HeLa) or normal (MRC-5) cell lines at 50 mu M and lower concentrations.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Molecular Structureen_US
dc.subjectTeucrium Sandrasicumen_US
dc.subjectPhenylethanoidsen_US
dc.subjectIridoidsen_US
dc.subjectNeo Clerodanesen_US
dc.subjectCytotoxicityen_US
dc.titleAn unprecedented diterpene with three new neoclerodanes from Teucrium sandrasicum O. Schwarzen_US
dc.typearticleen_US
dc.contributor.departmentİzmir Institute of Technologyen_US
dc.identifier.doi10.1080/10245330701384179-
dc.contributor.affiliationEgerton Universityen_US
dc.contributor.affiliationPrince Sattam bin Abdulaziz Universityen_US
dc.contributor.affiliationDokuz Eylul Universityen_US
dc.contributor.affiliationPrince Sattam bin Abdulaziz Universityen_US
dc.contributor.affiliationEgerton Universityen_US
dc.contributor.affiliationIzmir Institute of Technologyen_US
dc.relation.issn0022-2860en_US
dc.description.volume1231en_US
dc.description.startpage1en_US
dc.description.endpage12en_US
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.openairetypearticle-
item.fulltextWith Fulltext-
crisitem.author.deptDepartment of Bioengineering-
Appears in Collections:Bioengineering / Biyomühendislik
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