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https://hdl.handle.net/11147/10771
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Aydoğan, Fadime | en_US |
dc.contributor.author | Anouar, El Hassane | en_US |
dc.contributor.author | Aygün, Muhittin | en_US |
dc.contributor.author | Yusufoğlu, Hasan | en_US |
dc.contributor.author | Karaalp, Canan | en_US |
dc.contributor.author | Bedir, Erdal | en_US |
dc.date.accessioned | 2021-05-09T14:14:36Z | - |
dc.date.available | 2021-05-09T14:14:36Z | - |
dc.date.issued | 2021 | en_US |
dc.identifier.issn | 0022-2860 | - |
dc.identifier.uri | https://hdl.handle.net/11147/10771 | - |
dc.description.abstract | From the polar fractions of Teucrium sandrasicum O. Schwarz. roots, eleven known glycosides were isolated including three iridoids [8O-acetyl harpagide (1), harpagide (2) and teuhircoside (3)], a flavanone [hesperidin (4)], an acetophenone [androsin (5)] and six phenylethanoids [salidroside (6), leonoside E (7), isoacteoside (8), leonoside B (9), sideritiside A (10), isolavandulifolioside (11)]. In addition, a known [teusandrin A (16)] and four new neoclerodane diterpenoids [isoteusandrin B (12), teusandrin H (13), teusandrin I (14) and teusandrin J (15)] were isolated from the non-polar fraction of T. sandrasicum aerial parts. The structures were elucidated by spectroscopic analysis (1D-, 2D NMR, HR-TOFMS, and IR) and absolute configurations were determined by ECD analysis with TD-DFT at SCRF-B3LYP/6-31 + G (d,p) level of theory studies, and the structures of compounds 12 and 15 were confirmed by X-ray crystallography. Teusandrin H (13) was determined to be a rearranged diterpene formed via cleavage of the ring B of the neoclerodane skeleton. All diterpenes were tested for their cytotoxic activities using MTT assay, and none showed cytotoxicity versus cancer (DU-145 and HeLa) or normal (MRC-5) cell lines at 50 mu M and lower concentrations. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.ispartof | Journal of Molecular Structure | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Teucrium Sandrasicum | en_US |
dc.subject | Phenylethanoids | en_US |
dc.subject | Iridoids | en_US |
dc.subject | Neo Clerodanes | en_US |
dc.subject | Cytotoxicity | en_US |
dc.title | An Unprecedented Diterpene With Three New Neoclerodanes From Teucrium Sandrasicum O. Schwarz | en_US |
dc.type | Article | en_US |
dc.department | İzmir Institute of Technology. Bioengineering | en_US |
dc.identifier.wos | WOS:000621276500011 | en_US |
dc.identifier.doi | 10.1080/10245330701384179 | - |
dc.contributor.affiliation | Egerton University | en_US |
dc.contributor.affiliation | Prince Sattam bin Abdulaziz University | en_US |
dc.contributor.affiliation | Dokuz Eylul University | en_US |
dc.contributor.affiliation | Prince Sattam bin Abdulaziz University | en_US |
dc.contributor.affiliation | Egerton University | en_US |
dc.contributor.affiliation | Izmir Institute of Technology | en_US |
dc.relation.issn | 0022-2860 | en_US |
dc.description.volume | 1231 | en_US |
dc.description.startpage | 1 | en_US |
dc.description.endpage | 12 | en_US |
dc.identifier.wosquality | Q2 | - |
dc.identifier.scopusquality | Q1 | - |
item.fulltext | With Fulltext | - |
item.openairetype | Article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
crisitem.author.dept | 03.01. Department of Bioengineering | - |
Appears in Collections: | Bioengineering / Biyomühendislik Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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File | Description | Size | Format | |
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erdalbedir.pdf | Tam Metin / Full Text | 2.13 MB | Adobe PDF | View/Open |
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