Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/10435
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dc.contributor.authorÖzefe, Fatih-
dc.contributor.authorYıldız, Ahu Arslan-
dc.date.accessioned2021-01-24T18:43:10Z-
dc.date.available2021-01-24T18:43:10Z-
dc.date.issued2020-
dc.identifier.issn0003-2654-
dc.identifier.issn1364-5528-
dc.identifier.urihttps://doi.org/10.1039/d0an01111h-
dc.identifier.urihttps://hdl.handle.net/10435-
dc.descriptionPubMed: 32648883en_US
dc.description.abstractThis work describes development of smartphone-assisted magnetic levitation assay forPoint-of-Care(PoC) applications. Magnetic levitation is a technique that detects and separates particles based on their density differences in a magnetic field. Observation of the levitated micro-particles is mainly performed by light microscope or additional optical components, which mostly limits applicability of the magnetic levitation technique for PoC diagnostics. In this paper, we demonstrated the capability of the smartphone assisted-magnetic levitation platform for Hepatitis C (HCV) detection assay. This method utilizes microsensor beads (MS beads) that are functionalized with anti-HCV NS3 antibody. First, the magnetic levitation platform was optimizedviadensity marker polyethylene beads (DMB); then HCV NS3 protein was successfully detected based on levitation height differences of MS beads caused by density changes. The capability of the magnetic levitation platform for HCV detection was determined as almost 10-fold sensitive compared to conventional techniques such as enzyme-linked immunosorbent assay (ELISA). The imaging capability and resolution of the setup was improved over previously used configurations, and the developed platform enabled visualization of micro-scale objects only by smartphone assistance. This method requires no power, it is an easy-to-use and cost effective, therefore it could be easily adaptable to varied sensing assays as PoC tool.en_US
dc.language.isoenen_US
dc.publisherRoyal Society of Chemistryen_US
dc.relation.ispartofAnalysten_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleSmartphone-assisted Hepatitis C detection assay based on magnetic levitationen_US
dc.typeArticleen_US
dc.institutionauthorÖzefe, Fatih-
dc.institutionauthorYıldız, Ahu Arslan-
dc.departmentİzmir Institute of Technology. Bioengineeringen_US
dc.identifier.volume145en_US
dc.identifier.issue17en_US
dc.identifier.startpage5816en_US
dc.identifier.endpage5825en_US
dc.identifier.wosWOS:000561987500011en_US
dc.identifier.scopus2-s2.0-85089811102en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1039/d0an01111h-
dc.identifier.pmid32648883en_US
dc.relation.doi10.1039/d0an01111hen_US
dc.coverage.doi10.1039/d0an01111hen_US
dc.identifier.wosqualityQ1-
dc.identifier.scopusqualityQ1-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.languageiso639-1en-
item.fulltextNo Fulltext-
crisitem.author.dept01. Izmir Institute of Technology-
crisitem.author.dept03.01. Department of Bioengineering-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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