Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/9305
Title: AltORFev facilitates the prediction of alternative open reading frames in eukaryotic mRNAs
Authors: Kochetov, Alex V.
Allmer, Jens
Klimenko, Alexandra I.
Zuraev, Bulat S.
Matushkin, Yury G.
Lashin, Sergey A.
Allmer, Jens
Izmir Institute of Technology. Molecular Biology and Genetics
Issue Date: 2017
Publisher: Oxford University Press
Abstract: Motivation: Protein synthesis is not a straight forward process and one gene locus can produce many isoforms, for example, by starting mRNA translation from alternative start sites. altORF evaluator (altORFev) predicts alternative open reading frames within eukaryotic mRNA translated by a linear scanning mechanism and its modifications (leaky scanning and reinitiation). The program reveals the efficiently translated altORFs recognized by the majority of 40S ribosomal subunits landing on the 50-end of an mRNA. This information aids to reveal the functions of eukaryotic genes connected to synthesis of either unknown isoforms of annotated proteins or new unrelated polypeptides.
Description: Lashin, Sergey/0000-0003-3138-381X; Klimenko, Alexandra I/0000-0003-1877-9107; Allmer, Jens/0000-0002-2164-7335
WOS: 000397986500018
PubMed: 28039164
URI: https://doi.org/10.1093/bioinformatics/btw736
https://hdl.handle.net/11147/9305
ISSN: 1367-4803
1460-2059
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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