Essential oil loaded mucoadhesive nanocomposite delivery system for gastrointestinal system

Abstract

Current treatments for H. pylori infection are not efficient enough due to poor diffusion of antibiotics to mucus layer, low stability, side effects and insufficient residence time of antibiotics in gut, antibiotic resistance of H. pylori and allergy of patients against antibiotics. Therefore, alternative therapies including new drugs and therapeutic approaches with enhanced action and reduced side effects are needed to achieve high eradication rate of the bacteria. This invention is related with eradication and/or prevention therapy of H.pylori that provides better diffusion to mucus layer and stabilization in gastric conditions. This invention comprises the local treatment of H.pylori and/or improving the drug release profiles of encapsulated essential oil within chitosan/nanoclay microspheres which could be located in gastrointestinal system. Therefore, the aim of this invention is to encapsulate essential oil in gastroretentive chitosan/nanoclay spheres which has antimicrobial activity against H.pylori and release in a controlled manner in the prior to art.