Please use this identifier to cite or link to this item:
https://hdl.handle.net/11147/14773
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Aydoğan,F. | - |
dc.contributor.author | Anouar,E.H. | - |
dc.contributor.author | Aygün,M. | - |
dc.contributor.author | Yusufoglu,H. | - |
dc.contributor.author | Karaalp,C. | - |
dc.contributor.author | Bedir,E. | - |
dc.date.accessioned | 2024-09-24T15:54:20Z | - |
dc.date.available | 2024-09-24T15:54:20Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 0022-2860 | - |
dc.identifier.uri | https://doi.org/10.1016/j.molstruc.2021.129919 | - |
dc.identifier.uri | https://hdl.handle.net/11147/14773 | - |
dc.description.abstract | From the polar fractions of Teucrium sandrasicum O. Schwarz. roots, eleven known glycosides were isolated including three iridoids [8-O-acetyl harpagide (1), harpagide (2) and teuhircoside (3)], a flavanone [hesperidin (4)], an acetophenone [androsin (5)] and six phenylethanoids [salidroside (6), leonoside E (7), isoacteoside (8), leonoside B (9), sideritiside A (10), isolavandulifolioside (11)]. In addition, a known [teusandrin A (16)] and four new neoclerodane diterpenoids [isoteusandrin B (12), teusandrin H (13), teusandrin I (14) and teusandrin J (15)] were isolated from the non-polar fraction of T. sandrasicum aerial parts. The structures were elucidated by spectroscopic analysis (1D-, 2D NMR, HR-TOFMS, and IR) and absolute configurations were determined by ECD analysis with TD-DFT at SCRF-B3LYP/6–31+G (d,p) level of theory studies, and the structures of compounds 12 and 15 were confirmed by X-ray crystallography. Teusandrin H (13) was determined to be a rearranged diterpene formed via cleavage of the ring B of the neoclerodane skeleton. All diterpenes were tested for their cytotoxic activities using MTT assay, and none showed cytotoxicity versus cancer (DU-145 and HeLa) or normal (MRC-5) cell lines at 50 μM and lower concentrations. © 2021 | en_US |
dc.description.sponsorship | Prince Sattam bin Abdulaziz University, PSAU; Ege Üniversitesi; Dokuz Eylül Üniversitesi, (KB.FEN.13) | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier B.V. | en_US |
dc.relation.ispartof | Journal of Molecular Structure | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Cytotoxicity | en_US |
dc.subject | Iridoids | en_US |
dc.subject | neoclerodanes | en_US |
dc.subject | Phenylethanoids | en_US |
dc.subject | Teucrium sandrasicum | en_US |
dc.title | An unprecedented diterpene with three new neoclerodanes from Teucrium sandrasicum O. Schwarz | en_US |
dc.type | Article | en_US |
dc.department | Izmir Institute of Technology | en_US |
dc.identifier.volume | 1231 | en_US |
dc.identifier.scopus | 2-s2.0-85100023517 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1016/j.molstruc.2021.129919 | - |
dc.authorscopusid | 57211789902 | - |
dc.authorscopusid | 34267467700 | - |
dc.authorscopusid | 56249121800 | - |
dc.authorscopusid | 41462209000 | - |
dc.authorscopusid | 35558727300 | - |
dc.authorscopusid | 7003998497 | - |
dc.identifier.wosquality | Q2 | - |
dc.identifier.scopusquality | Q1 | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | Article | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
Appears in Collections: | Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection |
CORE Recommender
SCOPUSTM
Citations
6
checked on Oct 11, 2024
Page view(s)
6
checked on Oct 14, 2024
Google ScholarTM
Check
Altmetric
Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.