Tumor-specific genetic profiling and therapy in biomedicine

Abstract

Cancer cells divide continuously without any control, rendering immortal cells. These changes cause the dynamic instability in their genomes. Therefore each cancer cell in a tumor mass has various changes for specific tumor types. Their differences should be diagnosed on the basis of mutated genes and/or proteins. After the detection of alterations in cancer cells based on the techniques and instruments of biomedicine, personalized therapy continues with preexisting drug implementations. Personalized therapy broadens the borders with circulating tumor cells causing the metastasis in distant regions, developing specific gene therapies, novel targeted drugs, and immunotherapeutics for eliminating cancerous cells precisely. Within this context, biomedicine helps humankind to merge the biological and physiological knowledge to clinical practice. In this chapter, we aimed to clarify attitudes in biomedicine from molecular changes from single tumor cells to in vivo studies to find the best therapy for a cancer patient. © 2020 Elsevier Inc. All rights reserved.