Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/14671
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dc.contributor.authorJafari, Nahideh-
dc.contributor.authorMohammadpourfard, Mousa-
dc.contributor.authorHamishehkar, Hamed-
dc.date.accessioned2024-09-24T15:47:32Z-
dc.date.available2024-09-24T15:47:32Z-
dc.date.issued2024-
dc.identifier.issn1773-2247-
dc.identifier.issn2588-8943-
dc.identifier.urihttps://doi.org/10.1016/j.jddst.2024.106133-
dc.identifier.urihttps://hdl.handle.net/11147/14671-
dc.description.abstractMagnetic Fe3O4 nanoparticles (MNPs) hold significant potential across various scientific fields due to their notable properties. For biomedical applications, MNPs must be biocompatible, stable, and possess high magnetic potential. Aspartic acid (ASP) as a coating agent not only provides biocompatibility, stability, and high magnetic potential but also offers the potential for absorbing various drugs for targeted delivery due to its carboxyl and amino functional groups. So, in this study, we synthesized ASP-coated MNPs (ASP-MNPs) through a one-step co-precipitation method and loaded doxorubicin (DOX) onto these nanoparticles to create DOX-ASP-MNPs for targeted drug delivery. Characterization of the nanoparticle confirmed the crystal structure, spherical morphology, and improved size distribution of ASP-MNPs (8.53 +/- 2.56 nm) compared to uncoated MNPs (7.05 +/- 1.89 nm), as analyzed by XRD, FESEM, and TEM. FT-IR and zeta potential assessments (ZP = -6.3 mV for MNPs, ZP = -31.1 mV for ASP-MNPs) verified successful ASP binding, DOX loading, and nanoparticle stability. VSM analysis indicated a slight decrease in saturation magnetism after coating (51.1 emu/g) compared to MNPs (57.4 emu/g). In vitro release studies demonstrated a higher release rate (83 %) of DOX-ASP-MNPs at pH 5.2, indicating their suitability for cancerous cells. Cytotoxicity assays on A-549 cancer cell lines showed a dose-dependent response. DAPI staining revealed that free DOX caused more DNA damage. Cellular uptake studies indicated a time-dependent uptake of DOX-ASP-MNPs, higher at 3 h compared to 1 h, though lower than free DOX uptake due to different uptake pathways. Apoptosis assays over 72 h showed similar apoptotic rates for DOX-ASP-MNPs and free DOX. These findings suggest that ASP-MNPs possess enhanced physicochemical properties and effective drug delivery capabilities, making them a promising candidate for different biomedical applications, particularly targeted cancer therapy.en_US
dc.description.sponsorshipINSF (Iran National Science Foundation) [99009953]en_US
dc.description.sponsorshipThe authors are grateful to INSF (Iran National Science Foundation) for supporting this research with grant number 99009953.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCost-effective synthesisen_US
dc.subjectDrug deliveryen_US
dc.subjectLung canceren_US
dc.subjectMagnetic nanoparticlesen_US
dc.subjectAmio acidsen_US
dc.subjectApoptosisen_US
dc.titleA comprehensive study on doxorubicin-loaded aspartic acid-coated magnetic Fe<sub>3</sub>O<sub>4</sub> nanoparticles: Synthesis, characterization and in vitro anticancer investigationsen_US
dc.typeArticleen_US
dc.departmentIzmir Institute of Technologyen_US
dc.identifier.volume100en_US
dc.identifier.wosWOS:001313651200001-
dc.identifier.scopus2-s2.0-85202763928-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.jddst.2024.106133-
dc.authorscopusid56909731700-
dc.authorscopusid25522327900-
dc.authorscopusid14029889400-
dc.identifier.wosqualityQ1-
dc.identifier.scopusqualityQ1-
dc.description.woscitationindexScience Citation Index Expanded-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextnone-
crisitem.author.dept03.06. Department of Energy Systems Engineering-
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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