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Title: Biopatterning of 3d cellular structures via contactless magnetic manipulation for drug screening
Authors: Önbaş, Rabia
Arslan Yıldız, Ahu
Keywords: Contactless magnetic manipulation
3D cell culture
Drug screening assays
Publisher: Mary Ann Liebert
Abstract: "Patterning and manipulation techniques have been used to fabricate 3D cell cultures in tissue engineering. The contactless magnetic manipulation approach is a rapid, simple, and cost-effective method that requires paramagnetic agents [1-3] or magnetic materials [4]. Here, to obtain patterned 3D cellular structures a new alginate-based bio-ink formulation was developed to fabricate 3D cellular structures using contactless magnetic manipulation. 3D cardiac model was obtained by patterning rat cardiomyocytes. Cellular and extracellular components and cardiac-specific markers of patterned 3D cellular structures were indicated successfully. Drug response of patterned 3D cellular structures was evaluated by applying doxorubicin. Patterned 3D cardiac cellular structures showed significantly different drug response compared to conventional 2D cell cultures. In conclusion, this technique provides an easy, efficient, and low-cost methodology to fabricate 3D cardiac structures for drug screening.
Description: Tissue Engineering and Regenerative Medicine International Society (TERMIS) -- JUN 28-JUL 01, 2022 -- Krakow, POLAND
ISSN: 1937-3341
Appears in Collections:Bioengineering / Biyomühendislik
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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