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Title: Peptıde targeted core cross-lınked mıcelles for dox delıvery to HER2 expressıng cancer cells
Authors: Bayram, Nazende Nur
Ulu, Gizem Tuğçe
Gürdap, Seda
İşoğlu, İsmail Alper
Baran, Yusuf
Dinçer İşoğlu, Sevil
Keywords: Breast cancer
Core cross-linked micelles
HER2 targeting
Issue Date: Apr-2022
Publisher: Mary Ann Liebert
Abstract: In this study, we prepared a novel targeted and extra stable micellar nanocarrier that can facilitate intracellular drug release. First, ((N-3-sulfopropyl-N, N-dimethylammonium)ethyl methacrylate was synthesized by RAFT polymerization, and it was followed by copolymerization of macroCTA with AEM in the presence of an aciddegradable cross-linker. Then, a peptide estimated by phage display for HER-2 recognition was incorporated into these core cross-linked micelles with carbodiimide reaction.
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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