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Title: Survival impact of intervention to distant metastatic lesions in patients with breast cancer
Authors: Abidi, Hira
Ayoade, Oluwaseun
McAuliffe, Priscilla
Johnson, Ronald
Lee, Joanna
Keenan, Donald
Steiman, Jennifer
Sezgin, Efe
Soran, Atilla
Keywords: Breast cancer
Metastatic lesions
Publisher: Springer
Abstract: INTRODUCTION: Approximately 25% of patients (pts) with stage I - III breast cancer (BC) develop distant metastatic disease, a significant cause of mortality. The aim of this study is to evaluate whether intervention to metastatic lesions, in pts initially presenting with stage I–III BC, impacts overall survival (OS) and post-distant recurrence survival (PDRS). METHODS: This is a singleinstitution retrospective study of 201 pts with stage I–III BC, who subsequently develop metastatic lesions to the liver, lung, and/or bone, from 2006-2016. The cohorts included pts receiving intervention to their metastases (IM, n=100) versus no intervention to their metastases (NI, n=101). Two pts in the IM group were lost to follow up and excluded from the survival analysis. The primary study outcomes are OS and PDRS. The characteristics of the pts were compared with X2 test. OS curves were calculated by Kaplan-Meier method and multivariable analysis by Cox regression. Statistical significance was set at p< 0.05.
Appears in Collections:Food Engineering / Gıda Mühendisliği
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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