Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/12055
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dc.contributor.authorCömert, Meldaen_US
dc.contributor.authorBaran, Yusufen_US
dc.contributor.authorSaydam, Gürayen_US
dc.date.accessioned2022-04-19T09:17:03Z-
dc.date.available2022-04-19T09:17:03Z-
dc.date.issued2013-
dc.identifier.urihttps://hdl.handle.net/11147/12055-
dc.description.abstractChronic myeloid leukemia (CML) is a clonal myeloproliferative disease characterized by a reciprocal translocation between long arms of chromosomes 9 and 22 t(9; 22) that generates the BCR-ABL fusion gene. If left untreated, newly diagnosed chronic phase CML patients finally progress to accelerated and blastic phase. After the introduction of tyrosine kinase inhibitors (TKIs), treatment strategies of CML changed dramatically. However, the development of resistance to TKIs started to create problems over time. In this review, the current information about CML biology before and after imatinib mesylate treatment is summarized.en_US
dc.language.isoenen_US
dc.publishere-Century Publishing Corporationen_US
dc.relation.ispartofAmerican Journal of Blood Researchen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChronic myeloid leukemiaen_US
dc.subjectMoleculer biologyen_US
dc.subjectImatinib mesylateen_US
dc.titleChanges in molecular biology of chronic myeloid leukemia in tyrosine kinase inhibitor eraen_US
dc.typeArticleen_US
dc.institutionauthorBaran, Yusufen_US
dc.departmentİzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.wosWOS:000214940200001en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid23997982-
dc.contributor.affiliationEge Üniversitesien_US
dc.contributor.affiliationIzmir Institute of Technologyen_US
dc.contributor.affiliationEge Üniversitesien_US
dc.identifier.pmcidPMC3755521-
dc.relation.issn2160-1992en_US
dc.description.volume3en_US
dc.description.issue3en_US
dc.description.startpage191en_US
dc.description.endpage200en_US
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.languageiso639-1en-
item.fulltextWith Fulltext-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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