Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/11043
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dc.contributor.advisorYüksel Özşen, Aslı-
dc.contributor.authorGümüşbulut, Gülinen_US
dc.date.accessioned2021-08-06T08:32:14Z-
dc.date.available2021-08-06T08:32:14Z-
dc.date.issued2020-12en_US
dc.identifier.citationGümüşbulut, G. (2020). Extraction of oleuropein from olive leaves. . Unpublished master's thesis, İzmir Institute of Technology, İzmir, Turkey-
dc.identifier.urihttps://hdl.handle.net/11147/11043-
dc.descriptionThesis (Master)--Izmir Institute of Technology, Chemical Engineering, Izmir, 2020en_US
dc.descriptionIncludes bibliographical references (leaves. 59-69)-
dc.descriptionText in English; Abstract: Turkish and English-
dc.description.abstractThe aim of this study is to obtain oleuropein, which is the main phenolic compound content of olive leaf by soxhlet extraction. Oleuropein has been known in the health field for a long time and is found in high rates in our country. In this context, the effect of various solvent types (ethanol, methanol, acetonitrile and water), extraction time (4 cycles, 4 hours, 8 hours), particle size (250-500 µm and 900-2000 µm) and the pre-treatment applied to the olive leaf on the yield of oleuropein was investigated. The amount of oleuropein in the liquid product was determined using a High Performance Liquid Chromatogram (HPLC). When the grain size of the raw material to be used in extraction was reduced, higher oleuropein was obtained. The use of solvents in an aqueous form resulted in a higher amount of oleuropein compared to pure solvents. Increasing the extraction time caused a significant increase in the amount of oleuropein. On the contrary, it was observed that the pretreatment applied to olive leaves caused a decrease in the yield of oleuropein. As a result of these findings, the highest oleuropein amount and extraction efficiency were obtained after 8 hours of extraction period by using olive leaf with 250-500 μm grain size and 80% methanol solution as the solvent. The highest oleuropein amount was found to be 13.35 oleuropein mg/g dry leaves and the highest extraction efficiency under these conditions was found to be 36 %.en_US
dc.description.abstractBu çalışmanın amacı, sağlık alanında uzun süredir bilinen ve ülkemizde yüksek oranda bulunan zeytin yaprağının ana fenolik bileşik içeriği olan oleuropeini sokslet ekstraksiyonu ile elde etmektir. Bu bağlamda, çeşitli solvent tiplerinin (etanol, metanol, asetonitril ve su), ekstraksiyon süresinin (4 döngü, 4 saat, 8 saat), parçacık boyutunun (250-500 µm ve 900-2000 µm) ve zeytin yaprağına uygulanan ön işlemin oleuropein verimi üzerine etkileri araştırılmıştır. Sıvı ürün içindeki oleuropein miktarı Yüksek Performanslı Sıvı Kromatogram (HPLC) kullanılarak belirlenmiştir. Ekstraksiyonda kullanılacak hammaddenin parçacık boyutu küçüldüğünde daha yüksek oleuropein eldesi gözlemlenmiştir. Saf solventlere kıyasla sulu formdaki çözgenlerin kullanılması ile daha fazla miktarda oleuropein elde edilmesini sağlamıştır. Ekstraksiyon süresinin arttırılması, oleuropein miktarında önemli bir yükselmeyle sonuçlanmıştır. Bunun aksine zeytin yapraklarına uygulanan ön işlemin, oleuropein veriminde ve miktarında düşüşe neden olduğu gözlemlenmiştir. Bu deneyler sonucunda, en yüksek oleuropein miktarı ve ekstraksiyon verimi 250-500 μm parçacık boyutuna sahip zeytin yaprağı ve çözücü olarak 80 % metanol çözeltisi kullanılarak 8 saatlik ekstraksiyon süresi sonunda elde edilmiştir. En yüksek oleuropein miktarı 13.35 oleuropein mg/g kuru yaprak olarak bulunmuş ve en yüksek ekstraksiyon verimi bu koşullarda 36 % olarak bulunmuştur.en_US
dc.format.extentxi, 69 leaves-
dc.language.isoenen_US
dc.publisher01. Izmir Institute of Technologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOlive leavesen_US
dc.subjectOleuropeinen_US
dc.subjectExtraction (Chemistry)en_US
dc.titleExtraction of oleuropein from olive leavesen_US
dc.title.alternativeOleuropeinin zeytin yapraklarından özütlenmesien_US
dc.typeMaster Thesisen_US
dc.authorid0000-0002-5595-3074en_US
dc.departmentThesis (Master)--İzmir Institute of Technology, Chemical Engineeringen_US
dc.contributor.affiliation01. Izmir Institute of Technologyen_US
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeMaster Thesis-
item.languageiso639-1en-
item.fulltextWith Fulltext-
Appears in Collections:Master Degree / Yüksek Lisans Tezleri
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