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https://hdl.handle.net/11147/10123| Title: | Therapeutic Potential of Fisetin, Vitexin and Hesperetin on Chronic Myeloid Leukemia Cells | Authors: | Adan Gökbulut, Aysun Baran, Yusuf |
Publisher: | Elsevier Ltd. | Abstract: | In Chronic Myeloid Leukemia (CML) treatment, despite therapeutic efficacy of tyrosine kinase inhibitors, resistance development and side effects cause problems. Fisetin, vitexin and hesperetin are plant-derived flavonoids. In this study, therapeutic potentials of fisetin, vitexin and hesperetin were determined in CML cells. Cytotoxic effects of flavonoids were determined by MTT assay while apoptotic effects were determined by changes in caspase- 3 activity, loss of mitochondrial membrane potential (MMP) and Annexin V/PI double staining. Cytostatic effects of the flavonoids were evaluated by propidium iodide staining using flow cytometry. | Description: | 5th International Eurasian Hematology Congress | URI: | https://doi.org/10.1016/S0145-2126(14)70120-1 https://hdl.handle.net/11147/10123 |
ISSN: | 0145-2126 |
| Appears in Collections: | Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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| File | Size | Format | |
|---|---|---|---|
| 1-s2.0-S0145212614701225-main.pdf | 75.89 kB | Adobe PDF | View/Open |
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