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Therapeutic Potentials of Inhibition of Jumonji C Domain-Containing Demethylases in Acute Myeloid Leukemia

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dc.contributor.author Koca, Duygu
dc.contributor.author Kiraz, Yağmur
dc.contributor.author Hastar, Nurcan
dc.contributor.author Baran, Yusuf
dc.contributor.author Engür, Selin
dc.contributor.author Ulu, Gizem Tuğçe
dc.contributor.author Kiraz, Yağmur
dc.contributor.author Ulu, Gizem Tuğçe
dc.contributor.author Çekdemir, Demet
dc.contributor.author Baran, Yusuf
dc.contributor.other 01.01. Units Affiliated to the Rectorate
dc.contributor.other 04.03. Department of Molecular Biology and Genetics
dc.contributor.other 01. Izmir Institute of Technology
dc.contributor.other 04. Faculty of Science
dc.coverage.doi 10.4274/tjh.galenos.2019.2019.0083
dc.date.accessioned 2020-11-10T20:14:59Z
dc.date.available 2020-11-10T20:14:59Z
dc.date.issued 2020
dc.description.abstract Acute myeloid leukemia (AML) is a complex disease affected by both genetic and epigenetic factors. Histone methylation and demethylation are types of epigenetic modification in chromatin remodeling and gene expression. Abnormal expression of histone demethylases is indicated in many types of cancer including AML. Although many commercial drugs are available to treat AML, an absolute cure has not been discovered yet. However, inhibition of demethylases could be a potential cure for AML. Methylstat is a chemical agent that inhibits the Jumonji C domain-containing demethylases. en_US
dc.description.endpage 12 en_US
dc.description.issue 1 en_US
dc.description.startpage -5 en_US
dc.description.volume 37 en_US
dc.identifier.doi 10.4274/tjh.galenos.2019.2019.0083
dc.identifier.issn 13007777
dc.identifier.issn 13085263
dc.identifier.scopus 2-s2.0-85080841319
dc.identifier.uri https://hdl.handle.net/11147/9678
dc.identifier.uri https://search.trdizin.gov.tr/yayin/detay/365130
dc.language.iso en en_US
dc.publisher Aves en_US
dc.relation TUBITAK en_US
dc.relation.doi 10.4274/tjh.galenos.2019.2019.0083 en_US
dc.relation.grantno BIDEB 2209-A en_US
dc.relation.ispartof Turkish journal of haematology : Official journal of Turkish Society of Haematology en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Acute myeloid leukemia en_US
dc.subject Methylstat en_US
dc.subject Jumonji C domain en_US
dc.subject Histone methylation en_US
dc.title Therapeutic Potentials of Inhibition of Jumonji C Domain-Containing Demethylases in Acute Myeloid Leukemia en_US
dc.type Article en_US
dspace.entity.type Publication
gdc.author.institutional Koca, Duygu
gdc.author.institutional Hastar, Nurcan
gdc.author.institutional Kiraz, Yağmur
gdc.author.institutional Ulu, Gizem Tuğçe
gdc.author.institutional Baran, Yusuf
gdc.coar.access open access
gdc.coar.type text::journal::journal article
gdc.contributor.affiliation Moleküler Biyoloji ve Genetik Bölümü en_US
gdc.contributor.affiliation Moleküler Biyoloji ve Genetik Bölümü en_US
gdc.contributor.affiliation Anadolu Üniversitesi en_US
gdc.contributor.affiliation Moleküler Biyoloji ve Genetik Bölümü en_US
gdc.contributor.affiliation Moleküler Biyoloji ve Genetik Bölümü en_US
gdc.contributor.affiliation Sakarya Üniversitesi en_US
gdc.contributor.affiliation Moleküler Biyoloji ve Genetik Bölümü en_US
gdc.description.department İzmir Institute of Technology. Molecular Biology and Genetics en_US
gdc.description.scopusquality N/A
gdc.description.wosquality N/A
gdc.identifier.openalex W2999608793
gdc.identifier.pmid 31833715
gdc.identifier.trdizinid 365130
gdc.identifier.wos WOS:000514819900002
gdc.openalex.fwci 0.164
gdc.openalex.normalizedpercentile 0.5
gdc.opencitations.count 1
gdc.scopus.citedcount 5
gdc.wos.citedcount 5
local.message.claim 2022-12-08T16:31:59.712+0300 *
local.message.claim |rp00306 *
local.message.claim |submit_approve *
local.message.claim |dc_contributor_author *
local.message.claim |None *
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