WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7150

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Now showing 1 - 20 of 7153

Citation - WoS: 24
Effect of pH and Hydration on the Normal and Lateral Interaction Forces Between Alumina Surfaces
(2006) Polat, Mehmet; Sato, Kimiyasu; Nagaoka, Takaaki; Watari, Koji; 01. Izmir Institute of Technology; 03. Faculty of Engineering; 03.02. Department of Chemical Engineering
Normal and lateral interaction forces between alumina surfaces were measured using Atomic Force Microscopy-Colloid Probe Method at different pH. The normal force curves exhibit a well-defined repulsive barrier and an attractive minimum at acidic pH and the DLVO theory shows excellent agreement with the data. The normal forces are always repulsive at basic pH and the theory fails to represent the measurements. Lateral forces are almost an order of magnitude smaller in the basic solutions. These differences, which have important implications in the study of stability and rheology, are attributed to the hydration of the alumina surface at basic pH. © 2013 Elsevier B.V., All rights reserved.
Ephesos in a Capitalist World
(Green Lines inst Sustainable development, 2010) Akture, Z.; 01. Izmir Institute of Technology; 02. Faculty of Architecture; 02.02. Department of Architecture
In this paper, the use of the registered site of Ephesos for archaeological excavations and restorations that enliven tourism activities is analyzed as a response to mechanisms of the competitive market in our capitalist world, by putting the site to its socially most valued use and harvesting its productive capacity. The question remains whether the transformation of Ephesos into Turkey's most important tourism capital as such legitimizes its preservation as archaeological heritage, in the sense of public approval at large. The discussion is carried along the axis of property rights to decide whether or not a legitimacy crisis is being experienced in the Ephesos case. This is done by adopting Habermas' definition of crisis in accord with the idea of sustainability, as 'the phase of an illness in which it is decided whether or not the organism's self-healing powers are sufficient for recovery', to scrutinize the sustainability of preserving our archaeological heritage through tourism activities.
Hydrogen Production From Sugar Beet Wastewater in the Presence of Perovskite Type Catalysts by Photocatalysis
(Amer Chemical Soc, 2019) Ozsen, Asli Yuksel; Orak, Ceren; 01. Izmir Institute of Technology; 03. Faculty of Engineering; 03.02. Department of Chemical Engineering
Problem of Cracked Infinite Hollow Cylinder With Two Rigid Inclusions
(Civil Comp Press, 2000) Artem, HSA; Gecit, MR; 01. Izmir Institute of Technology; 03. Faculty of Engineering; 03.10. Department of Mechanical Engineering
This paper is concerned with the fracture of an axisymmetric hollow cylindrical bar containing rigid inclusions. The cylinder is under the action of uniformly distributed axial tension applied at infinity. The hollow cylinder contains a ring-shaped crack at the symmetry plane whose surfaces are free of tractions and two ring-shaped rigid inclusions with negligible thickness symmetrically located on both sides of the crack. Geometry and the loading is symmetric about z-axis. Along the rigid inclusions displacements are constant and continuous whereas stresses have jumps. The inner and the outer surfaces of the cylinder are free of tractions It is assumed that the material of the cylinder is linearly elastic and isotropic. The mixed boundary conditions of the problem lead the analysis to a system of three singular integral equations for crack surface displacement derivative and normal and shear stress jumps on rigid inclusions. These integral equations are solved numerically and the stress intensity factors at the edges of the crack and at the edges of the inclusions are calculated. Results are presented in graphical form.
Citation - WoS: 2
Citation - Scopus: 1
Çelik Fiber Katkısının Farklı Boyuna Donatı Oranına Sahip Betonarme Döşemelerin Zımbalama Davranışı Üzerinde Etkileri
(2019) Saatci, Selcuk; Yasayanlar, Suleyman; Yasayanlar, Yonca; Batarlar, Baturay; 01. Izmir Institute of Technology; 03. Faculty of Engineering; 03.03. Department of Civil Engineering
Sunulan çalışmada her iki yönde birbirine dik 0,004 (D1 serisi) ve 0,002 (D2 serisi) oranında boyuna donatıiçeren 2150x2150x150 mm boyutlarında iki grup betonarme döşeme, hacimce %0, %0,5, %1 ve %1,5oranında çelik fiber katkısı içeren beton karışımlarıyla dökülmüştür. Üretilen toplam sekiz döşeme ortanoktalarından statik yük altında test edilmişlerdir. Çelik fiber katkısı olmayan numunelerde yüksek boyunadonatı oranına sahip döşeme boyuna donatısında akma gerçekleşmeden gevrek bir şekilde zımbalamagöçmesi oluşurken düşük boyuna donatı oranına sahip döşeme zımbalama gerçekleşmeden önce çok dahasünek bir davranış göstermiştir. Çelik fiber katkısı her iki boyuna donatı oranında da iki kata varan oranlardazımbalama dayanımı artışlarına sebep olmuştur. Ancak D1 serisi döşemelerde çelik fiber katkısı maksimumyer değiştirmeleri önemli ölçüde arttırırken D2 serisinde maksimum yer değiştirmelerde önemli bir farkoluşmamış, bu döşemelerin yer değiştirmesi boyuna donatının akması tarafından kontrol edilmiştir. Çelikfiber katkısı oranının arttırılması D1 serisi döşemelerde dayanımın ve maksimum yer değiştirmelerinartmasına sebep olurken, D2 serisi döşemelerde %1'in üstü çelik fiber katkı oranları davranışta önemli birfark oluşturmamıştır. Yapılan deneyler Kritik Kesme Çatlağı Teorisi kullanılarak analitik olarakmodellenmiş ve bu tip modelleme ile ilgili bazı iyileştirmeler önerilmiştir.
Time-Resolved Stokes Polarization Analysis of Single Photon Emitters in Hexagonal Boron Nitride
(Amer Chemical Soc, 2025) Samaner, Caglar; Ates, Serkan; 01. Izmir Institute of Technology; 04. Faculty of Science; 04.05. Department of Pyhsics
Solid-state quantum emitters are pivotal to the advancement of quantum technologies, particularly in quantum computation and communication, where the polarization of single photons serves as a key information carrier. Precise characterization of polarization is essential for understanding the underlying dynamics and minimizing polarization-related errors in emitter design. In this study, we employ the Rotating Quarter-Wave Plate (RQWP) method to perform comprehensive polarization analysis of quantum emitters in hexagonal boron nitride (hBN). By capturing both time-averaged and time-resolved polarization characteristics, we present the first demonstration of dynamic Stokes parameter evolution from single-photon emitters in hBN. Our work demonstrates a powerful method for revealing complex polarization dynamics that were previously inaccessible and provides new insights into the behavior of solid-state quantum emitters. The methods introduced here are broadly applicable to polarization studies across a range of solid-state quantum systems.
The Influence of The Bauhaus Approach on Industrial Ceramic Design
(Anadolu Univ, 2025) Dogukan, Hazal; 01. Izmir Institute of Technology
The desire to move away from traditionalism caused by the intense discussions on art in the 19th and 20th centuries and to break traditional patterns that followed, initiated the search for new concepts, methods and techniques. In the Bauhaus School, the subjects of art and craft, form and meaning, aesthetics and function were reconsidered through different materials. Ceramics are also among the materials that gained a new meaning with Bauhaus. Before Bauhaus, ceramics, which were processed with detailed patterns and forms through handicraft and accepted as a traditional material, gained a modern and industrial identity in Bauhaus with standardized molds, forms suitable for function, far from processing and ornamentation. Bauhaus Ceramics Workshop has revealed approaches and methods that guide industrial ceramic design. The pots made by craftsmen have given way to minimal products designed with basic design principles and having a conceptual substructure. This innovation has formed the basis of the minimalism approach in today's industrial design. In line with the ideas and radical approach of the Bauhaus school, which started a new era for the field of design, this study aims to investigate the effects of the school on today's industrial ceramic product design, and many data found in the literature were used and content analysis was made on ceramic products made by Bauhaus artists. Bauhaus interpretations and reflections in industrial design were discussed. By presenting the Bauhaus references in ceramic product design, the study aims to contribute to the literature and offer a new perspective to researchers and designers in the field.
Deposition of (La,Sr)CoO₃-δ and (La,Sr)₂CoO₄-δ Cathode Layers on Gadolinia-Doped Ceria by Electrospray Deposition
(Springer, 2025) Ergen, Emre; Akkurt, Sedat; 01. Izmir Institute of Technology; 03. Faculty of Engineering; 03.09. Department of Materials Science and Engineering
La-, Sr-, and Co-based oxides have proven their performances in the cathode layers of intermediate temperature levels of solid oxide fuel cells (SOFC), and hence have been frequently studied. They are deposited on the electrolyte layer by chemical vapor deposition (CVD), screen printing, pulsed laser deposition (PLD), etc. The electrospray deposition (ESD) proved itself as an effective and facile method for cathode deposition. Cathode layers deposited on gadolinia-doped ceria (GDC) with the compositions of (La0.5Sr0.5)CoO3, (La0.8Sr0.2)CoO3, (La0.5Sr0.5)2CoO4, and (La0.8Sr0.2)2CoO4 are known to provide low resistance values which are critical in cell performance. In this study, ESD is used for the first time as the coating method of these compositions. Area-specific resistance (ASR) measurements made by electrochemical impedance spectroscopy (EIS) showed promising results. Particularly, the sample coated in (La0.5Sr0.5)CoO3 composition showed an ASR value of 0.11 Omega.cm2 at 700 degrees C. ESD showed the ability to control the cathode coating microstructure by controlling the spraying parameters.
Making Hierarchically Aware Decisions on Short Findings for Automatic Summarisation
(Elsevier, 2025) Inan, Emrah; 01. Izmir Institute of Technology; 03. Faculty of Engineering; 03.04. Department of Computer Engineering
An impression in a typical radiology report emphasises critical information by providing a conclusion and reasoning based on the findings. However, the findings and impression sections of these reports generally contain brief texts, as they highlight crucial observations derived from the clinical radiograph. In this scenario, abstractive summarisation models often experience a degradation in performance when generating short impressions. To address this challenge in the summarisation task, our work proposes a method that combines well-known fine-tuned text classification and abstractive summarisation language models. Since fine-tuning a language model requires an extensive, well-defined training dataset and is a time-consuming task dependent on high GPU resources, we employ prompt engineering, which uses prompt templates to programme language models and improve their performance. Our method first predicts whether the given findings text is normal or abnormal by leveraging a fine-tuned language model. Then, we apply a radiology-specific BART model to generate the summary for abnormal findings. In the zero-shot setting, our method achieves remarkable results compared to existing approaches on a real-world dataset. In particular, our method achieves scores of 37.43 for ROUGE-1, 21.72 for ROUGE-2, and 35.52 for ROUGE-L.
A Critical Analysis of Pulverization Mechanism During Hydrogen Decrepitation of End-Of Ndfeb Magnets
(Elsevier Science Sa, 2025) Habibzadeh, Alireza; Gokelma, Mertol; 01. Izmir Institute of Technology; 03. Faculty of Engineering; 03.09. Department of Materials Science and Engineering
Given the increasing demand and limited availability of rare earth elements (REEs), innovative solutions are critical to managing supply risks. Recycling is a key strategy in mitigating these risks, particularly for NdFeB magnets, which consume a large portion of REEs. Among the various recycling processes, hydrogen decrepitation (HD) has gained popularity due to its efficiency in producing fine powders for magnet-to-magnet recycling. While the HD mechanism is commonly attributed to hydride formation in the Nd-rich grain boundary phase, this study presents new findings that challenge this assumption. Through the hydrogenation of End-of-Life (EoL) NdFeB magnets at temperatures ranging from 25 to 400 & ring;C, the results indicate that the primary mechanism of pulverization arises from hydride formation in the Nd2Fe14B matrix rather than in the Nd-rich phase, especially at low temperatures where NdH2 formation is kinetically unfavorable. This revised mechanism was supported by evidence from X-ray diffraction, BSE and SE-SEM imaging, particle size analysis, diffusion modeling, and stress analysis.
Traditional Water Harvesting Systems in Climate Change Adaptation: Insights From a Semi-Arid Mediterranean Village
(Middle East Technical Univ, 2025) Gercek, Deniz; Yuceer, Hulya; Gonulal, Yasemin Ozcan; Ustuk, Ozan; Uzelli, Taygun; Guler, Selen; Baba, Alper; 01. Izmir Institute of Technology; 02. Faculty of Architecture; 02.01. Department of Conservation and Restoration of Cultural Heritage; 02.03. Department of City and Regional Planning; 03. Faculty of Engineering; 03.03. Department of Civil Engineering; 01.01. Units Affiliated to the Rectorate
Traditional water harvesting systems (WHS), developed over centuries by past civilizations, have long played a crucial role in addressing water scarcity in semi-arid regions. Although these systems have been largely neglected with the expansion of modern water infrastructure, they remain a valuable heritage containing significant knowledge and practices that are still relevant today, particularly in overcoming water management challenges in the face of climate change. Although traditional WHSs have been studied across various regions, their forms and functions vary significantly due to unique climatic, geological, and cultural conditions. In the Mediterranean context, small-scale WHSs have received comparatively limited attention-particularly studies that integrate both their revitalization for contemporary use and their historical and cultural significance. This study aims to help bridge that gap and contribute the existing literature by focusing on the WHSs in Barbaros, a semi-arid village on the Aegean coast of Turkey. Barbaros is particularly unique due to its special geological conditions, as the porous soil makes water retention difficult, which adds to the importance of traditional WHSs. In this context, the main objective of this research is to comprehensively assess these systems, by considering the area's topography, geological features, WHS construction techniques, and local knowledge transmitted across generations. This multidisciplinary approach, combining a literature review, field observations, expert surveys and interviews with long-time residents, enables a comprehensive analysis of the typologies, current state and socio-cultural evolution of these systems. A thorough understanding of these systems is essential to assess their resilience and relevance for climate change adaptation, especially with regard to drought management. The study concludes that, despite their partial abandonment, the traditional WHSs in Barbaros offer valuable insights into sustainable water management and demonstrate their potential as practical models for addressing today's water challenges.
Effect of Partial Austenitization Treatment on Microstructure and Mechanical Properties for Multiphase Steels
(Springer, 2025) Erisir, Ersoy; Sari, Elif; Kocakusakli, Emre; Dulger, Nurten Basak; Oktay, Serkan; Tutuk, Ramazan; Davut, Kemal
In this study, the microstructural evolution and mechanical properties of a 0.15 pct C-2.09 pct Mn multiphase steel was investigated. To produce a multiphase microstructure, a newly developed two-step processing of partial austenitization and quenching (PAQ) treatment was used. In the first step, the steel with initial martensitic microstructure was partially austenitized at 690 degrees C for 8 hours. After cold rolling, a rapid reheating to 840 degrees C and quenching done to simulate hot dip galvanizing conditions. To better understand the PAQ process, thermodynamic and kinetic simulations using ThermoCalc and DICTRA predicted phase transformations and elemental partitioning. Microstructural characterization via LM, SEM, and EBSD revealed an ultrafine-grained multiphase structure consisting of bainite, M/A, and intercritical ferrite. The PAQ840 sample showed an ultimate tensile strength of 740 MPa and excellent ductility with 20 pct total elongation.
A Novel Vulnerability Index and Approach for Improving Road Network Vulnerability
(Canadian Science Publishing, 2025) Dogaroglu, Bora; Pelin Çalişkanelli, S.; 01. Izmir Institute of Technology
A transportation network’s recovery depends on its vulnerability to disaster impacts and functionality restoration. This study proposes two novel indexes for comprehensively measuring the vulnerability of road networks: link vulnerability measurement and node vulnerability measurement. Analyses were conducted on a hypothetical road network using dynamic assignment in the PTV VISSIM microsimulation environment, and the network vulnerabilities were calculated using the proposed methods. The results were compared with those found in the literature. Additionally, a method was proposed to reduce the vulnerability of the road network, and the proposed approach was compared with the current situation. The results showed 13.09% and 14.83% improvements in the average link vulnerability and node vulnerability values, respectively. In terms of achieving a more balanced distribution of vulnerability across the system, improvements of 5.68% and 41.35% were observed in the standard deviations of the link vulnerability and node vulnerability values, respectively. © 2025 Elsevier B.V., All rights reserved.
Nanoencapsulation of Hydroxytyrosol Extract of Fermented Olive Leaf Brine Using Proniosomes
(Wiley, 2025) Kadiroglu, Pinar; Kilincli, Betul; Ilgaz, Ceren; Bayindir, Zerrin Sezgin; Kelebek, Hasim; Helvacioglu, Selin; Ozhan, Gunes
BACKGROUND: Olive leaves are rich in bioactive compounds with potential health benefits; however, their limited bioavailability and stability hinder their effective utilization. Emerging technologies, nanocarrier-based delivery systems, have shown promise in enhancing these properties. RESULTS: The optimal conditions for proniosome formulation were 50 rpm rotational speed and 35 degrees C, achieving 81.20 +/- 0.80% encapsulation efficiency. Particle sizes ranged from 188.6 to 248.9 nm, with a zeta potential of similar to-30 mV, indicating high stability and resistance to aggregation. Advanced instrumental analysis confirmed interactions between the extract and proniosome components. After 30 days at 4 degrees C, extract-loaded proniosomes maintained better homogeneity and lower polydispersity index. Cytotoxicity studies showed that both the extract and its proniosomal form were nontoxic to HEK293T cells up to 200 mu g mL(-1). In zebrafish assays, minimal larval mortality was observed up to 3200 mu g mL(-1) for the extract, while no mortality occurred up to 1600 mu g mL(-1) for the proniosomal extract, highlighting its improved safety profile. CONCLUSION: The findings from this research could contribute to the advancement of sustainable and health-promoting food innovations by integrating cutting-edge nanotechnology-driven encapsulation strategies into plant-based food formulations. (c) 2025 Society of Chemical Industry.
A Robust Possibilistic Semi-Supervised Fuzzy Clustering Algorithm With Neighborhood-Aware Feature Weighting
(Springer Heidelberg, 2025) Moghaddam, Arezou Najafi; Aghazadeh, Nasser; Hashemzadeh, Mahdi; Oskouei, Amin Golzari
The Semi-Supervised Fuzzy C-Means (SSFCM) method integrates class distribution information with fuzzy logic to overcome the challenges of semi-supervised clustering methods. While the inclusion of label information in the objective function improves the quality of the clustering method, semi-supervised fuzzy techniques still encounter important limitations, including (1) sensitivity to noise and outliers, (2) uniform feature importance, (3) neglecting the influences of neighborhood in the clustering process. In this paper, an improved semi-supervised clustering algorithm is presented to address these challenges. First, the algorithm reduces the sensitivity to noise and outliers by integrating the possibilistic fuzzy C-means algorithm into the SSFCM method. Second, a dynamic feature weighting method assigns different weights to the features in each cluster, which improves the performance of the algorithm in imbalanced datasets. Third, the proposed algorithm introduces a neighborhood mechanism that incorporates the neighbor's trade-off weighting and feature weighting strategy considering a strong metric. Finally, a robust kernel metric is used to further improve the performance on complex and nonlinear datasets. Extensive experiments are conducted on several benchmark datasets to evaluate the performance of the proposed method. The results show that the proposed method outperforms the current state-of-the-art techniques. The implementation source codes of the proposed method are publicly available at https://github.com/Amin-Golzari-Oskouei/RPSSFC-NAFW.
The Infinitude of the Primes and Some Coloring Theorems
(Taylor & Francis inc, 2025) Adibelli, Azem Berivan; Goral, Haydar
We first prove the infinitude of the primes via a special case of Rado's theorem whose proof is based on the infinite Ramsey theorem. In the proof, we use the colorings of the positive integers introduced by Levent Alpoge [1] and Andrew Granville [2]. Finally, using Rado's theorem for integral domains, we will give another proof for the infinitude of nonassociated prime elements in any unique factorization domain R with a few units.
Citation - Scopus: 1
Investigation on the Keggin Anchored on Hydroxide-Functionalized Single-Walled Carbon Nanotubes as Superior Cathode for Aqueous Zinc-Ion Batteries
(American Chemical Society, 2025) Chilufya, Langson; Sertbaş, Vahide; Aytekin, Ahmet; Karabudak, Engin; Emirdag-Eanes, Mehtap; 01. Izmir Institute of Technology; 04. Faculty of Science; 04.01. Department of Chemistry
Rechargeable aqueous zinc-ion batteries (AZIBs) have become a viable option in electrochemical energy storage systems (EESS) owing to their inherent safety features and economic friendliness. Nonetheless, creating suitable cathode materials for AZIBs with high structural stability, good rate performance, and great capacity remains a significant challenge. Polyoxometalate (POM)-based nanohybrid materials have shown promising results in high cycling stability and great specific capacity. However, POMs susceptible to electrolyte dissolution and the sluggish Zn-ion (Zn2+) kinetics have significantly hampered their electrochemical performance as cathodes for AZIBs. Herein, we present a Keggin POM, K3[PW12O40]·nH2O (KPW12), anchored on hydroxyl (OH)-functionalized single-walled carbon nanotubes (SWOH) that were fabricated via a facile ultrasonication procedure. Employed as cathodes for AZIBs, the optimal KPW12/SWOH feature exhibited remarkable electrochemical performance. The system satisfied the Zn2+storage, achieving a reversible discharge capacity of 183 mAh g–1at a high current density of 5C with a flat and long discharge plateau after 160 cycles. The perfect synergistic contribution of the pseudocapacitive nature of the super-reduced state of KPW12and the electron-conductive network of SWOH was attributed to this exceptional electrochemical performance. Furthermore, the presence of oxygen in SWOH enhanced the transfer kinetics of electrons and smooth Zn2+diffusion while lowering the Zn2+migration energy barrier by providing more accessible active sites. This demonstrates remarkable promise in fabricating robust electrode materials optimized for integration within aqueous battery systems that pave the way for further research into POM-based materials for EESS. © 2025 Elsevier B.V., All rights reserved.
Planning Competencies and Transformative Pedagogy for Sustainable Development
(Pergamon-Elsevier Science Ltd, 2025) Bafarasat, Abbas Ziafati; Baker, Mark; Cheshmehzangi, Ali; Goodspeed, Robert; Scott, Mark; Sharifi, Ayyoob; Katsigianni, Xenia
Understood as "a means by which society decides collectively what urban [and rural] change should be like and tries to achieve that vision by a mix of means.", there is broad consensus that planning should fully incorporate the notion of sustainable development. Planners have a critical role in envisioning and driving local transitions to sustainable development. This requires transforming what planners learn and how they learn in higher education. This study is the first to identify a set of planning competencies for sustainable development. It proposes in three areas planning competencies for sustainable development, including (a) knowledge to understand human settlements, (b) skills to plan sustainable settlements, and (c) values to stand for sustainable communities. Following a conceptual analysis of transformative pedagogy as a superior theoretical approach to teaching for sustainable development, this study is also the first to identify types of transformative learning activities, including (1) unlearning- relearning activities, (2) learning through new experiences, and (3) ill-structured problem solving. The study therefore makes original contributions to both planning and education literature, in addition to its interdisciplinary methodological contribution through an original design of 'framing and
Silver-Loaded Titania-Based Metal-Organic Frameworks as a Platform for Silver Ion Release for Antibacterial Applications
(American Chemical Society, 2025) Mazare, Anca; Goldmann, Wolfgang Heinrich; Kocak, Esra; Osuagwu, Benedict; Qin, Shanshan; Cao, Ran; Schmuki, Patrik; 01. Izmir Institute of Technology
Conventional Ag-decorated TiO2coatings suffer from low adsorption capacity and burst release kinetics, limiting long-term antibacterial efficacy and risking cytotoxicity. An entirely different payload release approach can be based on metal–organic frameworks (MOFs), which offer tunable porosity, high surface area, and internal diffusion channels. Here, we report a thermally stabilized Ti-based MOF [NH2-MIL-125(Ti)] functionalized with Ag+via reactive deposition, enabling high Ag loading (∼14.7 wt %) and sustained release. Annealing at 250 °C enhances aqueous stability, allowing diffusion-governed Ag+delivery over >48 h, with 77% of the Ag still present in the MOF after a 24 h release. The system exhibits dose-dependent antibacterial activity in powders and comparable efficacy in coatings, with a more gradual release profile. This scalable platform is promising for long-acting coatings, wound interfaces, and implantable materials. © 2025 Elsevier B.V., All rights reserved.
Enhanced Doxorubicin Cytotoxicity on Breast Cancer Spheroids by Aptamer Targeted Co-Delivery With Hyaluronidase
(Wiley, 2025) Kavruk, Murat; Demirel, Dide Su; Bonyadi, Farzaneh; Guner, Buket Cakmak; Dursun, Ali Dogan; Vakifahmetoglu, Cekdar; Ozalp, Veli Cengiz
Breast cancer is one of the most prevalent solid tumors in women and can be classified into subtypes based on molecular characteristics, such as hormone receptor status and HER2 expression. Aptamers, highly specific affinity molecules, are extensively studied for targeted drug delivery using nanocarriers to enhance anti-cancer efficacy. This study focused on HER2-responsive co-delivery of doxorubicin and hyaluronidase via aptamer-gated mesoporous silica nanoparticles to improve therapeutic outcomes in solid tumors. SK-BR-3 spheroids are employed as a model for resistant tumor environments in solid tumors. Previous research is shown that conjugating cytotoxic drugs with nanoparticles or cells enhances drug penetration into tumor spheroids. In this work, doxorubicin is loaded into mesoporous silica nanoparticles and capped with HER2-specific aptamers, while the particle surface is functionalized with hyaluronidase. This dual-functionalized nanocarrier system achieves an approximate to 8.5-fold increase in cytotoxicity compared to aptamer-targeted delivery lacking hyaluronidase. The enhanced effect is attributed to hyaluronidase-mediated loosening of the spheroid structure, facilitating nanoparticle penetration and localized release of doxorubicin at high concentrations on HER2-positive cells.

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