Sürdürülebilir Yeşil Kampüs Koleksiyonu / Sustainable Green Campus Collection
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report.listelement.badge İzmir Institute of Technology Sustainability Report 2023(01. Izmir Institute of Technology, 2023)The IZTECH Sustainable Green Campus Coordinatorship was founded in 2014. A search conference for a sustainable living campus with the tagline “happy campus” was held with the campus actors’ collective participation. However, it was not until December 2019 that a Framework on Sustainable Campus was defined. IZTECH has decided to apply the UI GreenMetric for critical self-evaluation and development in the field of sustainability in 2020 and continued to do so in 2021 and 2022 as well. With the motto of “happy campus, happy peninsula, happy Izmir,” the IZTECH Sustainable Green Campus Coordination group was formed. It consists of 12 academics including our rector, our academicians who are expert in the field and young and enthusiastic teaching assistants. Most importantly, our Coordinatorship continues today thanks to the support of eco motion and numerous other student communities. As a result, we are able to assure the sustainability of our campus through bottom-up development.report.listelement.badge İzmir Institute of Technology Sustainability Report 2022(01. Izmir Institute of Technology, 2022)İzmir Institute of Technology (IZTECH) aims at creating a sustainable and resilient campus environment that outreaches the boundaries of the campus in order to serve the in-campus and out-campus communities alike. In line with this main aim, IZTECH has initiated application to the Greenmetric World University Ranking that was developed by Universitas Indonesia. Therefore, IZTECH has undertaken a gap analysis in terms of its sustainability performance by determining the current situation and the future targets. There were 6 main topics to investigate and eventually improve: Setting and Infrastructure, Energy and Climate, Waste, Water, Transportation, Education and Research. October 2022 marks IZTECH’s third year of application to the Greenmetric Ranking. • In its first year IZTECH was ranked 217th out of 912 institutions. • In its second year, IZTECH was ranked 198th out of 956. In order to determine the scopes to develop and improve from each ranking IZTECH endeavors to create a sustainable campus environment. With a motto of “happy campus, happy peninsula, happy Izmir”, the IZTECH Sustainable Green working group was set up – consisting of 35 volunteering academics, employers, researchers, assistants as well as 15 students from the Eco-motion Student initiative - for a sustainable future.report.listelement.badge İzmir Institute of Technology Sustainability Report 2021(01. Izmir Institute of Technology, 2021)İzmir Institute of Technology (IZTECH) aims at creating a sustainable and resilient campus environment that outreaches the boundaries of the campus in order to serve the in-campus and out-campus communities alike. In line with this main aim, IZTECH has initiated application to the Greenmetric World University Ranking that was developed by Universitas Indonesia. Therefore, IZTECH has undertaken a gap analysis in terms of its sustainability performance by determining the current situation and the future targets. There were 6 main topics to investigate and eventually improve: Setting and Infrastructure, Energy and Climate, Waste, Water, Transportation, Education and Research. October 2021 marks IZTECH’s second year of application to the Greenmetric Ranking. In its first year IZTECH was ranked 217th out of 912 institutions. In order to determine the scopes to develop and improve from each rankingIZTECH endeavors to create a sustainable campus environmentArticle Citation - WoS: 15Citation - Scopus: 18Groundwater Recharge Estimation Using Hydrus 1d Model in Alaşehir Sub-Basin of Gediz Basin in Turkey(Springer Verlag, 2019-10) Tonkul, Serhat; Tonkul, Serhat; Baba, Alper; Demirkesen, Ali Can; Şimşek, Celalettin; Tayfur, Gökmen; Durukan, Seda; Baba, Alper; Demirkesen, Ali Can; Tayfur, Gökmen; 03.06. Department of Energy Systems Engineering; 02.03. Department of City and Regional Planning; 03.03. Department of Civil Engineering; 03. Faculty of Engineering; 02. Faculty of Architecture; 01. Izmir Institute of TechnologyGediz Basin, located in the western part of Turkey constituting 2% land of the country, has an important groundwater potential in the area. Alasehir sub-basin, located in the southeast of the Gediz Basin and subject to the extensive withdrawal for the irrigation, constitutes the study area. Natural recharge to the sub-basin due to precipitation is numerically investigated in this study. For this purpose, 25 research wells, whose depths range from 20 to 50 m, were drilled to observe the recharge and collect the necessary field data for the numerical model. Meteorological data were collected from 3 weather stations installed in the study area. The numerical model HYDRUS was calibrated using the field water content data. Soil characterization was done on the core samples; the aquifer characterization was performed, and the alluvial aquifer recharge due to precipitation was calculated. As a result, the computed recharge value ranges from 21.78 to 68.52 mm, with an average value of 43.09 mm. According to the numerical model, this amount of recharge corresponds to 10% of the amount of annual rainfall.Article Citation - WoS: 3Ecophysiological Properties of Turkish Endemic Centaurea Consanguinea Dc.(Parlar Scientific Publications, 2019) Eskin, Bülent; Doğan, İlhan; Özyiğit, İbrahim İlker; Doğan, İlhan; Demir, Göksel; Yarcı, Celal; Serin, Memduh; 04.03. Department of Molecular Biology and Genetics; 04. Faculty of Science; 01. Izmir Institute of TechnologyThis physiological and ecological study was performed on Centaurea consanguinea DC. to acquire information about certain characteristics (bioclimatic, edaphic, topographic, biotic etc.) of its habitat and distribution in Turkey, determine the requirements for germination, explore the soil-plant relations and obtain data on certain aspects of its population biology. Plant and co-located soil samples were collected from Amasya and Havza District (Samsun) in Turkey using standard methods. Various analyzes were employed for determining of physical, chemical and biological properties of the plant species and its co-located soils including pH, total protein and electrical conductivity (EC), soil texture, contents of mineral nutrition and other physical and chemical parameters and the results were presented. Nutrient amounts (in %) were found to be in the ranges of 0.01-0.007 for N, 0.0008-0.001 for P, 0.01-0.09 for K, 0.0002-0.0003 for Na in the soils and 2.25 for N, 0.0068 for P, 0.07 for K and 0.02 for Na in the plant, respectively. Also, it was observed that germination ratios of the seeds were depended on various factors.Article Citation - WoS: 13Citation - Scopus: 18Brominated Flame Retardants in a Computer Technical Service: Indoor Air Gas Phase, Submicron (pm1) and Coarse (pm10) Particles, Associated Inhalation Exposure, and Settled Dust(Elsevier Ltd., 2019-09) Genişoğlu, Mesut; Genişoğlu, Mesut; Sofuoğlu, Aysun; Sofuoğlu, Sait Cemil; Kurt Karakuş, Perihan Binnur; Sofuoğlu, Aysun; Birgül, Aşkın; Sofuoğlu, Sait Cemil; 03.02. Department of Chemical Engineering; 03.07. Department of Environmental Engineering; 03. Faculty of Engineering; 01. Izmir Institute of TechnologyBrominated flame retardants (BFRs) are found in multi-media indoors, therefore, may pose serious risks to human health. This study investigated the occurrence of BFRs in particulate matter (PM1 and PM10) and gas phase by active and passive sampling, and settled dust to estimate potential exposure in a computer technical service. Polybrominated diphenyl ethers (PBDEs) and their alternatives (novel BFRs, NBFRs) were studied. PM and gas phase were collected on glass fiber filters and polyurethane foam plugs, respectively, and analyzed with a GC/MS after extraction, clean-up, and concentration. Inhalation exposure of the staff was estimated based on the measured concentrations using Monte Carlo simulation. BDE-209 was the dominating PBDE congener in all media while bis(2-ethylhexyl)-3,4,5,6-tetrabromophthalate and 1,2-bis(2,4,6-tribromophenoxy)ethane were those of NBFRs. Submicron particulate matter (PM1) BFR levels constituted about one half of the PM10-associated concentrations, while average PM10 mass concentration (69.9 μg m−3) was nine times that of PM1 (7.73 μg m−3). Calculated log10 dust-gas and PM-gas partitioning coefficients ranged from −5.03 to −2.10, −2.21 to −0.55, and −2.26 to −1.04 for settled dust, PM10, and PM1, respectively. The indoor/outdoor concentration ratios were >1 for all compounds indicating the strength of indoor sources in the service. The estimated potential inhalation exposures, for future chronic-toxic and carcinogenic risk assessments, indicated that the levels of gas-phase and PM1-associated exposures were similar at approximately one half of PM10-associated levels. Results of this study indicate that the occurrence of BFRs in all studied media should be taken into consideration for occupational health mitigation efforts.Article Citation - WoS: 2Citation - Scopus: 2A Deterministic and Stochastic Assessment for Exposure and Risk of Arsenic Via Ingestion of Edible Crops(Springer Verlag, 2019-09) Can Terzi, Begüm; Gündüz, Orhan; Gündüz, Orhan; Sofuoğlu, Sait Cemil; Sofuoğlu, Sait Cemil; 03.07. Department of Environmental Engineering; 03. Faculty of Engineering; 01. Izmir Institute of TechnologyNatural arsenic contamination is a critical problem for various places around the world. Simav Plain (Kutahya, Turkey) is one such area that was shown to have natural arsenic contamination in its waters and soils. Arsenic exposure through ingestion of edible crops cultivated in Simav Plain and associated health risks were assessed in this study. To achieve this objective, arsenic levels in 18 crop species were estimated based on measured soil arsenic concentrations. Individual and aggregate non-carcinogenic and carcinogenic risks associated with ingestion of arsenic-contaminated crops were then assessed with scenario-based deterministic point estimates and stochastic population estimates. Monte Carlo simulation was used for the estimation of population health risks. Accordingly, wheat was found as the highest-ranked crop specie for the both types of health risks, followed by tomato and potato, which are three of the most consumed crops in the region. The risk levels estimated in this study were relatively high, indicating consumption of crops grown in the plain may be posing significant health risks even at lower-bound estimates. Consuming wheat, tomato, potato, and their products from uncontaminated sources was found to reduce the aggregate risks up to 88% implicating the importance of proposing suitable management measures for similar risk-prone areas.Article Citation - WoS: 26Citation - Scopus: 27Fast Formation of Nitro-Pahs in the Marine Atmosphere Constrained in a Regional-Scale Lagrangian Field Experiment(American Chemical Society, 2019-08) Mulder, Marie D.; Sofuoğlu, Sait Cemil; Dumanoğlu, Yetkin; Sofuoğlu, Aysun; Efstathiou, Christos; Kukucka, Petr; Matejovicova, Jana; Maurer, Christian; Pribylova, Petra; Prokes, Roman; Sofuoğlu, Aysun; Sofuoğlu, Sait Cemil; Wilson, Jake; Zetzsch, Cornelius; Wotawa, Gerhard; Lammel, Gerhard; 03.02. Department of Chemical Engineering; 03.07. Department of Environmental Engineering; 03. Faculty of Engineering; 01. Izmir Institute of TechnologyPolycyclic aromatic hydrocarbons (PAHs) and some of their nitrated derivatives, NPAHs, are seemingly ubiquitous in the atmospheric environment. Atmospheric lifetimes may nevertheless vary within a wide range, and be as short as a few hours. The sources and sinks of NPAH in the atmosphere are not well understood. With a Lagrangian field experiment and modeling, we studied the conversion of the semivolatile PAHs fluoranthene and pyrene into the 2-nitro derivatives 2-nitrofluoranthene and 2-nitropyrene in a cloud-free marine atmosphere on the time scale of hours to 1 day between a coastal and an island site. Chemistry and transport during several episodes was simulated by a Lagrangian box model i.e., a box model coupled to a Lagrangian particle dispersion model, FLEXPART-WRF. It is found that the chemical kinetic data do capture photochemical degradation of the 4-ring PAHs under ambient conditions on the time scale of hours to 1 day, while the production of the corresponding NPAH, which sustained 2-nitrofluoranthene/fluoranthene and 2-nitropyrene/pyrene yields of (3.7 ± 0.2) and (1.5 ± 0.1)%, respectively, is by far underestimated. Predicted levels of NPAH come close to observed ones, when kinetic data describing the reactivity of the OH-adduct were explored by means of theoretically based estimates. Predictions are also underestimated by 1-2 orders of magnitude, when NPAH/PAH yields reported from laboratory experiments conducted under high NOx conditions are adopted for the simulations. It is concluded that NPAH sources effective under low NOx conditions, are largely underestimated.Article Citation - WoS: 38Citation - Scopus: 41Chloride or Sulfate? Consequences for Ozonation of Textile Wastewater(Academic Press Inc., 2019-10) Öktem, Yalçın Aşkın; Ökten, Hatice Eser; Yüzer, Burak; Aydın, Muhammed Iberia; Ökten, Hatice Eser; Meriç, Süreyya; Selçuk, Hüseyin; 03.07. Department of Environmental Engineering; 03. Faculty of Engineering; 01. Izmir Institute of TechnologyOzonation of chloride-rich textile wastewater is a common pretreatment practice in order to increase biodegradability and therefore meet the discharge limits. This study is the first to investigate ozone-chloride/bromide interactions and formation of hazardous adsorbable organic halogens (AOX) in real textile wastewater. Initially effect of ozonation on chloride-rich real textile wastewater samples were investigated for adsorbable organic halogens (AOX) formation, biodegradability and toxicity. After 15 min of ozonation, maximum levels of chlorine/bromine generation (0.3 mg/l) and AOX formation (399 mg/l) were reached. OUR and SOUR levels both increased by approximately 58%. Daphnia magna toxicity peaked at 100% for 10 min ozonated sample. Considering adverse effects of ozonation on chloride-rich textile industry effluents, we proposed replacement of NaCl with Na2SO4. Comparative ozonation experiments were carried out for both chloride and sulfate containing synthetic dyeing wastewater samples. Results showed that use of sulfate in reactive dyeing increased biodegradability and decreased acute toxicity. Although sulfate is preferred over chloride for more effective dyeing performance, the switch has been hampered due to sodium sulfate's higher unit cost. However, consideration of indirect costs such as contributions to biodegradability, toxicity, water and salt recovery shall facilitate textile industry's switch from chloride to sulfate.Article Citation - WoS: 39Citation - Scopus: 44Experimental and Numerical Investigation of Forced Convection in a Double Skin Façade by Using Nodal Network Approach for Istanbul(Elsevier Ltd., 2019-05) İnan, Tuğba; Başaran, Tahsin; Başaran, Tahsin; 02.02. Department of Architecture; 02. Faculty of Architecture; 01. Izmir Institute of TechnologyIn this study, temperature distribution and heat transfer through the cavity of a double skin façade (DSF) was investigated in the laboratory environment and analyzed numerically by using nodal network approach. The verification of the nodal network method was conducted by using data from the steady-state experiments and the same method was applied for the climate of Istanbul, Turkey under unsteady outside boundary conditions. Furthermore, heat gain and loss values in DSF for January and July were calculated and compared with single skin façade (SSF) application for different directions of the façades. The results were given for a day and a working time period of the office buildings by using monthly average daily climate data. Distinction working hours were more convenient to investigate the energy performance of DSF because of solar radiation effect. Using DSF in all directions, the cooling loads decreased up to 26% comparing to the SSF. DSF system was disadvantageous comparing to the SSF for January. However, it was shown that the heated air in the cavity could be used for preheating process of air in a HVAC system for winter period.Article Citation - WoS: 2Citation - Scopus: 2Energy Performance Assessment in Terms of Primary Energy and Exergy Analyses of the Nursing Home and Rehabilitation Center(SAGE Publications Inc., 2019-12) Hancıoğlu Kuzgunkaya, Ebru; Hancıoğlu, Ebru; 01. Izmir Institute of TechnologyThis paper concerns with the energy analysis (based on primary energy) and exergy analysis of Narlıdere Nursing Home and Rehabilitation Center (NNHRC) in İzmir, Turkey that was chosen as a sample public building. The Center services as a nursing and rehabilitation center for the aged and it also includes a geriatric division operating as a hospital. The Center was analyzed using the actual energy consumption data derived from several energy audits. Energy efficiency (according to the primary energy ratio) and exergy efficiency of the facility were calculated to be 59% and 14%, respectively. The results have indicated that the exergy efficiencies of space heating and cooling have the lowest values compared with the other units of facility. Specific primary energy consumption and specific exergy consumption of the facility were found to be 271.91 kWh/m2 year and 290.23 kWh/m2 year, respectively. Sustainability index value of the overall NNHRC was found to be 1.621.Article Citation - WoS: 5Citation - Scopus: 5Effect of Chain Topology on Plasmonic Properties of Pressure Sensor Films Based on Poly(acrylamide) and Au Nanoparticles(Elsevier Ltd., 2019-08) Topçu, Gökhan; Demir, Mustafa Muammer; Demir, Mustafa Muammer; 03.09. Department of Materials Science and Engineering; 03. Faculty of Engineering; 01. Izmir Institute of TechnologyAu nanoparticles have been recognized as a colorimetric sensing element in polymeric systems because clustering shifts the red color of individual particles into saturated blue due to distinct plasmonic variation. The mechanism of pressure sensing is based on the disintegration of the particle clusters into the individual particles in polymers upon application of pressure. Polymers are usually composed of linear chains that provide a viscoelastic medium for their diffusion. Changing topology of polymer chains from linear to crosslinked under fixed pressure makes a clear change in spectral features of the particles probably due to the hindrance of particle diffusion by the crosslinking points. Therefore, the working range of the sensor films can be increased to higher-pressure values. In this work, polyacrylamide/Au nanoparticle films were prepared by various concentrations of formaldehyde as a crosslinking agent from 0.5 to 5.0 wt %. The initial absorption signal gradually shifts from 690 to 545 nm for linear chains upon application of pressure while shifting goes down to 571 nm for crosslinked ones. The colorimetric change is also examined under humid environments. Contrary to the crosslinking process, humid environment facilitates the diffusion of particles since the chains swell with water molecules that provide a convenient medium for particle diffusion.Conference Object Citation - WoS: 12Citation - Scopus: 15Drying of Olive Leaves in a Geothermal Dryer and Determination of Quality Parameters of Dried Product(Elsevier, 2019) Helvacı, Hüseyin Utku; Helvacı, Hüseyin Utku; Menon, Abhay; Gökçen Akkurt, Gülden; Aydemir, Levent Yurdaer; Korel, Figen; Korel, Figen; Gökçen Akkurt, Gülden; 01. Izmir Institute of Technology; 03.08. Department of Food Engineering; 03.06. Department of Energy Systems Engineering; 03. Faculty of EngineeringIn this study, a cabinet type geothermal dryer was designed, operated and tested for drying olive leaves with minimum losses of phenolic content and antioxidant capacity by optimization of drying conditions. Two factors; face centered central composite design was applied and response surface methodology was used to optimize the drying conditions of olive leaves. The results indicate that phenolic content stability were mainly affected by air temperature, whereas antioxidant capacity is affected by both air temperature and velocity (p<0.05). The optimal drying conditions were found to be at 50°C of air temperature and 1 m/s of air velocity for the minimum losses of determined quality parameters, where 88.8% of phenolic content and 95.3% of antioxidant capacity were recovered.Article Citation - WoS: 1Citation - Scopus: 1Dovecotes in Kayabağ Village: an Assessment of Landscape and Architectural Characteristics(Taylor and Francis Ltd., 2020-01) İnceköse, Ülkü; İnceköse, Ülkü; 02.02. Department of Architecture; 02. Faculty of Architecture; 01. Izmir Institute of TechnologyThe dovecotes of Kayseri-Gesi stand out as unique examples of indigenous architecture of Anatolia. They are considered significant elements of the rural landscape. The purpose of the construction, the constructional and spatial characteristics peculiar to these dovecotes, make them an important element of global cultural and architectural heritage. Dovecotes that are built upon rocks, with mere building stones provided from the same rocks, look like a shaped form of the topography itself. This is very much to do with the geological features of the Cappadocia Region where Kayseri is located. In terms of construction techniques and spatial organization, the dramatic differences in the dovecotes’ underground and aboveground parts make them even more outstanding. This research is based on the field studies conducted in the dovecotes of Kayabağ. The landscape was studied in all aspects and each dovecote is studied for its placement, topographical interactions, plan and section typologies, materiality and construction techniques. The structural problems stemmed from the geological features and the deterioration caused by external factors are taken into consideration. The study concludes with an overall approach for preservation, sustainability and conservation process of the heritage landscape of Dovecotes [Güvercinlik] of Kayabağ.Article Citation - WoS: 33Citation - Scopus: 34Development of High Flux Nanofiltration Membranes Through Single Bilayer Polyethyleneimine/Alginate Deposition(Elsevier Ltd., 2019-03) Tekinalp, Önder; Alsoy Altınkaya, Sacide; Alsoy Altınkaya, Sacide; 03.02. Department of Chemical Engineering; 03. Faculty of Engineering; 01. Izmir Institute of TechnologyThe aim of this study is to prepare high flux, stable, antifouling nanofiltration membranes through single bilayer polyelectrolyte deposition. To this end, a tight ultrafiltration support membrane was prepared from a polysulfone/sulfonated polyethersulfone blend. Deposition of a polyethyleneimine and alginate pair on this support has reduced the molecular weight cut off from 6 kDa to below 1 kDa. The pure water permeability and polyethylene glycol 1000 rejection of the coated membrane were found to be 15.5 ± 0.3 L/m2·h·bar and 90 ± 0.6%, respectively, by setting the deposition pH for each layer to 8 and the ionic strengths to 0.5 M and 0 M. This membrane has exhibited significantly higher permeability than commercial membranes with the same molecular weight cut off, retaining 98% of the initial flux during 15 h filtration of bovine serum albumine. In addition, the membrane has been able to completely remove anionic dyes from aqueous solution by showing 99.9% retentions to Reactive red 141, Brilliant blue G and Congo red with a 2 bar transmembrane pressure. High flux and membrane stability in acidic and salty environments have been achieved when deposition conditions favor high adsorption levels for the first layer and strong ionic cross-linking between the carboxyl group on the alginate and the amine groups on the polyethyleneimineArticle Citation - WoS: 5Citation - Scopus: 6Development of an Optical Tyrosinase Biosensor (tca) for Detection of “parathion-Methyl”(Emerald Group Publishing Ltd., 2019-07) Polatoğlu, İlker; Çakıcıoğlu Özkan, FehimePurpose: This paper aims to present a novel and cost-effective optical biosensor design by simple preparation method for detection of “parathion-methyl,” which is a model pesticide pose to public health and the environment. Design/methodology/approach: The optical enzyme biosensor (TCA) for detection of pesticide “parathion-methyl” was developed on the basis of immobilization of tyrosinase enzyme on chitosan film by adsorption technique. The analytic performance of TCA was investigated by measuring its activity with Ultraviolet (UV) visible spectrophotometer. Findings: Uniform porous network structure and protonated groups of chitosan film provided a microenvironment for tyrosinase immobilization evident from Fourier transform infrared (FTIR) spectroscopy and Atomic Force Microscopy analysis. TCA has a wide linear detection range (0-1.03 µM) with high correlation coefficient and it can detect the parathion-methyl concentration as low as 159 nM by noncompetitive inhibition kinetics. Using the TCA sensor both for ten times and at least 45 days without a significant loss in its activity are the indicators of its good operational and storage stability. Moreover, TCA can be applicable to tap water, providing a promising tool for pesticides detection. Originality/value: This is the first time to use the in situ analytical technique that can improve the performance of optical enzyme sensor provided to control the pesticide residue better with respect to traditional techniques. The effect of organic solvents on the performance of optical enzyme biosensor was investigated. Inhibition kinetic of the solvents rarely encountered in literature was also studied besides the pH and temperature tolerance of the optical biosensor.Article Citation - WoS: 23Citation - Scopus: 30Chitosan/Montmorillonite Composite Nanospheres for Sustained Antibiotic Delivery at Post-Implantation Bone Infection Treatment(IOP Publishing Ltd., 2019-05) Kımna, Ceren; Tıhmınlıoğlu, Funda; Değer, Sibel; Tamburacı, Sedef; Tıhmınlıoğlu, Funda; 03.02. Department of Chemical Engineering; 03. Faculty of Engineering; 01. Izmir Institute of TechnologyDespite the advancements in bone transplantation operations, inflammation is still a serious problem that threatens human health at the post-implantation period. Conventional antibiotic therapy methods may lead to some side effects such as ototoxicity and nephrotoxicity, especially when applied in high doses. Therefore, local drug delivery systems play a vital role in bone disorders due to the elimination of the disadvantages introduced by conventional methods. In the presented study, it was aimed to develop Vancomycin (VC) and Gentamicin (GC) loaded chitosan-montmorillonite nanoclay composites (CS/MMT) to provide required antibiotic doses to combat post-implantation infection. CS/MMT nanocomposite formation was supplied by microfluidizer homogenization and spherical drug carrier nanoparticles were obtained by electrospraying technique. Three factors; voltage, distance and flowrate were varied to fabricate spherical nanoparticles with uniform size. Emprical model was developed to predict nanosphere size by altering process variables. Nanospheres were characterized in terms of morphology, hydrodynamic size, zeta potential, drug encapsulation efficiency and release profile. Drug loaded nanospheres have been successfully produced with a size range of 180-350 nm. Nanocomposite drug carriers showed high encapsulation efficiency (80%-95%) and prolonged release period when compared to bare chitosan nanospheres. The drug release from nanocomposite carriers was monitored by diffusion mechanism up to 30 d. The in vitro release medium of nanospheres showed strong antimicrobial activity against gram-positive S. aureus and gram-negative E. coli bacteria. Furthermore, it was found that the nanospheres did not show any cytotoxic effect to fibroblast (NIH/3T3) and osteoblast (SaOS-2) cell lines. The results demonstrated that the prepared composite nanospheres can be a promising option for bone infection prevention at the post implantation period.Article Citation - WoS: 2Citation - Scopus: 3Can Tube Tunnel Crossings Relieve Urban Congestion Problems? Izmir Tube Tunnel Project Proposal Under Scrutiny(MDPI Multidisciplinary Digital Publishing Institute, 2019-05) Duvarcı, Yavuz; Duvarcı, Yavuz; Yiğitcanlar, Tan; 02.03. Department of City and Regional Planning; 02. Faculty of Architecture; 01. Izmir Institute of TechnologyBuilding underwater tube tunnel crossings to ease the urban congestion problems has become a popular approach for many cities across the globe. London, New York, Istanbul, Hamburg, Sydney and Brisbane are among these cities. However, the effectiveness and externalities of these expensive mega urban infrastructures have also been questioned widely among urban, transport and environmental planning scholars. Given the international popularity of the topic, this study places a new tube tunnel crossings project from Izmir, Turkey under the microscope. In this heuristic simulation study, policy-on scenarios were tested to determine possible impacts of the underwater tube tunnel-crossing project. The traffic impacts are discussed using simulations assigning the initial origin-destination data. The results of the study revealed that, given the two locations, outer and inner locations over the dagger-shape bay, the capacity increments on the bridge links and the links around the periphery highway did not bring any effective solutions beyond some minor improvements. The findings disclosed that the ineffectiveness of the tube tunnel crossing might be due to the excessive congestion happening all over the downtown area, which clogs the passageways to the bridge. The paper highlights the limitations of the tube tunnel-crossing project, emphasises the need for comprehensive investigations before committing to the project and advocates the emphasis to be actually given for sustainable mobility.Conference Object Citation - WoS: 3Citation - Scopus: 4Biofabrication of Cellular Structures Using Weightlessness as a Biotechnological Tool(IEEE, 2019) Anıl İnevi, Müge; Yaman, Sena; Sarıgil, Öykü; Sarıgil, Öykü; Yaman, Sena; Anıl İnevi, Müge; Yalçın Özuysal, Özden; Yalçın Özuysal, Özden; Meşe, Gülistan; Meşe Özçivici, Gülistan; Tekin, Hüseyin Cumhur; Özçivici, Engin; Özçivici, Engin; Tekin, Hüseyin Cumhur; Meşe Özçivici, Gülistan; 03.01. Department of Bioengineering; 01. Izmir Institute of Technology; 04.03. Department of Molecular Biology and Genetics; 03. Faculty of Engineering; 04. Faculty of ScienceGravity is an important biomechanical signal effecting the morphology and function of organisms. Reduction of gravitational forces, as experienced during spaceflight, cause alterations in the biological systems. Magnetic levitation technique is one of the most recent ground-based technology to mimic weightlessness environment. In addition to providing a platform to investigate biological effects of the weightlessness, this platform presents a novel opportunity to biofabricate 3-dimensional (3D) structures in a scaffold-and nozzle-free fashion. In this study, various controllable self-assembled 3D living structures were fabricated via magnetic levitation technique. This strategy may offer an easy and cost-effective opportunity for a wide range of space biotechnology researches.Conference Object Citation - WoS: 4Citation - Scopus: 5Application of Magnetic Levitation Induced Weightlessness To Detect Cell Lineage(IEEE, 2019) Sarıgil, Öykü; Anıl İnevi, Müge; Anıl İnevi, Müge; Sarıgil, Öykü; Yılmaz, Esra; Meşe Özçivici, Gülistan; Çağan, Melike; Tekin, Hüseyin Cumhur; Meşe, Gülistan; Özçivici, Engin; Tekin, Hüseyin Cumhur; Meşe Özçivici, Gülistan; Özçivici, Engin; 03.01. Department of Bioengineering; 01. Izmir Institute of Technology; 04.03. Department of Molecular Biology and Genetics; 03. Faculty of Engineering; 04. Faculty of ScienceIdentification and classification of bone marrow cells is an important step for molecular biology and therapeutic studies related to bone marrow disorders such as osteoporosis or obesity. In this study, we applied magnetic levitation technology to induce a weightlessness environment to detect adipocytes and osteoblasts based on their single cell density. This biotechnological method can be used for separation of heterogeneous populations such as bone marrow once adapted to a continuous microfluidic platform.
