Browsing by Author "Çağır, Ali"

6-Bicycloaryl substituted (S)- and (R)-5,6-dihydro-2H-pyran-2-ones: Asymmetric synthesis, and anti-proliferative properties

Kasaplar, Pınar; Yılmazer, Özgür; Çağır, Ali (Elsevier, 2009-01)

(R)-Goniothalamin, is a member of styryl lactones, possesses selective cytotoxicity against cancer cell lines. In this work, replacement of styryl substituent with 2-naphthyl and 3-quinoyl gave new analogues which may have ...

Antiproliferative properties of 2'-alkoxymethyl substituted klavuzon derivatives

Yıldız, Mehmet Salih (Izmir Institute of Technology, 2017-07)

One of the main objectives of studies on anticancer agents is that the agent is expected to show a high cytotoxic activity on cancer cells and show a less cytotoxic effect on the contrary in healthy cells or never show ...

Asymmetric synthesis and anti-tumor properties of conformationally constrained analogues of (S)-and (R)-goniothalamin

Kasaplar, Pınar (İzmir Institute of Technology, 2008)

Naturally isolated 5-substituted-a,B-unsaturated-.-lactones gained great attention of researchers due to their cytotoxic and anti-tumor properties. Styryl lactones are the most interesting members of this group of naturally ...

Asymmetric synthesis of 5,6-dihydro-2H-pyran-2-one derivatives

Akçok, İsmail (İzmir Institute of Technology, 2014)

α,β-unsaturated lactone derivatives are very important structural core which are isolated from nature and shown as source for several biological activities. Biologically active styryl δ-lactones are well known α,β-unsatu ...

Cleavage of ring A and formation of an unusual nor-triterpene skeleton via the Baeyer-Villiger reaction

Tağ, Özgür; Çağır, Ali; Khan, Ikhlas A.; Bedir, Erdal (Elsevier, 2012-10)

With the aim to generate a compound library for our biological screening studies, cycloastragenol was subjected to chemical transformation studies. The Baeyer-Villiger oxidation experiments provided an interesting ...

Combinatorial libraries of stilbene fused chalcone and flavanone derivatives: Synthesis and anti-proliferative properties

Akçok, İsmail (İzmir Institute of Technology, 2009)

Flavonoids and stilbenes have attracted great attention as potential pharmaceuticals. Up to date more than 5000 natural flavonoid derivatives have been isolated from natural resources. Flavonoids are most commonly known ...

Comparison od side effects of anti-cancer drugs in 2D and 3D and, classical and cell-on-a-chip cultures

Kankale, Deniz (Izmir Institute of Technology, 2016-07)

The studies that aim to assess the effects of drugs developed against cancer at the cellular level use multiwell plates. However, these classical systems fail to reproduce the in-vivo like microenvironment necessary for ...

Composition of carotenoids in Scenedesmus protuberans: Application of chromatographic and spectroscopic methods

Erdoğan, Ayşegül; Çağır, Ali; Conk Dalay, Meltem; Eroğlu, Ahmet E. (Springer, 2015-09)

This study aimed to identify and determine the carotenoids from green microalga, Scenedesmus protuberans using analytical techniques. Identification of carotenoids was realized by comparing their absorption and mass spectral ...

CRM1 inhibitory and antiproliferative activities of novel 4′-alkyl substituted klavuzon derivatives

Kanbur, Tuğçe; Kara, Murat; Kutluer, Meltem; Şen, Ayhan; Delman, Murat; Alkan, Aylin; Otaş, Hasan Ozan; Akçok, İsmail; Çağır, Ali (Elsevier, 2017)

Klavuzons are 6-(naphthalen-1-yl) substituted 5,6-dihydro-2H-pyran-2-one derivatives showing promising antiproliferative activities in variety of cancer cell lines. In this work, racemic syntheses of nine novel 4′-alkyl ...

Electrospun amino-functionalized PDMS as a novel SPME sorbent for the speciation of inorganic and organometallic arsenic species†

Boyacı, Ezel; Horzum, Nesrin; Çağır, Ali; Demir, Mustafa M.; Eroğlu, Ahmet E. (Royal Society of Chemistry, 2013-09-19)

Sol–gel based amine-functionalized SPME fibers (PDMS-weak anion exchanger) were prepared and used for direct mode extraction of dimethylarsinic acid (DMA), monomethylarsonic acid (MMA), and arsenate (As(V)) from aqueous ...

The evaluation of antiproliferative and structural effects of statins on non-small-cell lung cancer cell line A549

Aksoy, Hatice Nurdan (Izmir Institute of Technology, 2019-07)

Statins are commonly prescribed anti-lipidemic and anti-cholesterol class of drugs. In addition to their major role, they have been found to have anti-cancer effects on in vitro, animal and clinical studies. The aim of ...

Fungal biotransformation of novel 20(27)- octanor cycloastragenol and biological activities of the purified metabolites

Duman, Seda (Izmir Institute of Technology, 2019-07)

Biotransformation is the chemical modifications performed by enzymes or living organisms. The difficulty and high cost of enzyme isolation and purification makes it more advantageous to use whole cell systems as biocatalysts. ...

Hydrothermal synthasis and investigation of catalytic activities of cerium oxide nanoparticles

Boz, Mithat (İzmir Institute of Technology, 2013)

Single crystalline cerium oxide nanoparticles were synthesized with hydrothermal method by mixing cerium nitrate [Ce(NO3)3.6H2O] aqueous solution with NaOH and urea. SEM, TEM and XRD characterization methods were used in ...

Investigation of stilbene-fused chalcone and flavanone derivatives for their cytotoxic and anti-cancer properties

Odacı, Burcu (İzmir Institute of Technology, 2012)

Stilbene, chalcone and flavanones are three major classes of molecules, which can be found in plants as secondary metabolites. Derivatives of those may possess variety of biological activities. In this study it is aimed ...

Investigation of the anti-cancer properties of novel 4'-alkyl substituated klavuzon derivatives on pancreatic cancer cell line

Şen, Ayhan (Izmir Institute of Technology, 2015-12)

In anti-cancer agent studies one of the important issue is to discover an agent that target specifically cancer cells with no or minimal effects on normal cells. (R)-goniothalamin, which is a styryl lactone isolated from ...