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Browsing by Author "Koca, Duygu"

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    Citation - WoS: 5
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    Therapeutic Potentials of Inhibition of Jumonji C Domain-Containing Demethylases in Acute Myeloid Leukemia
    (Aves, 2020) Koca, Duygu; Kiraz, Yağmur; Hastar, Nurcan; Baran, Yusuf; Engür, Selin; Ulu, Gizem Tuğçe; Kiraz, Yağmur; Ulu, Gizem Tuğçe; Çekdemir, Demet; Baran, Yusuf; 01.01. Units Affiliated to the Rectorate; 04.03. Department of Molecular Biology and Genetics; 01. Izmir Institute of Technology; 04. Faculty of Science
    Acute myeloid leukemia (AML) is a complex disease affected by both genetic and epigenetic factors. Histone methylation and demethylation are types of epigenetic modification in chromatin remodeling and gene expression. Abnormal expression of histone demethylases is indicated in many types of cancer including AML. Although many commercial drugs are available to treat AML, an absolute cure has not been discovered yet. However, inhibition of demethylases could be a potential cure for AML. Methylstat is a chemical agent that inhibits the Jumonji C domain-containing demethylases.