• Türkçe
    • English
  • English 
    • Türkçe
    • English
  • Login
View Item 
  •   DSpace@IZTECH
  • 9. Araştırma Çıktıları / Research Outputs
  • WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
  • View Item
  •   DSpace@IZTECH
  • 9. Araştırma Çıktıları / Research Outputs
  • WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Characterization of long living yeast deletion mutants that lack mitochondrial metabolism genes DSS1, PPA2 and AFG3

Thumbnail

View/Open

Makale (Article) (855.2Kb)

Access

info:eu-repo/semantics/closedAccess

Date

2019-07

Author

Muid, Khandaker Ashfaqul
Kimyon, Önder
Reza, Shahadat Hasan
Karakaya, Hüseyin Çağlar
Koç, Ahmet

Metadata

Show full item record

Abstract

Molecular mechanisms of aging and longevity are still mostly unknown. Mitochondria play central roles in cellular metabolism and aging. In this study, we identified three deletion mutants of mitochondrial metabolism genes (ppa2 Delta, dss1 Delta, and afg3 Delta) that live longer than wild-type cells. These long-lived cells harbored significantly decreased amount of mitochondria] DNA (mtDNA) and reactive oxygen species (ROS). Compared to the serpentine nature of wild-type mitochondria, a different dynamics and distribution pattern of mitochondria were observed in the mutants. Both young and old long-lived cells produced relatively low but adequate levels of ATP for cellular activities. The status of the retrograde signaling was checked by expression of CIT2 gene and found activated in long-lived mutants. The mutant cells were also profiled for their gene expression patterns, and genes that were differentially regulated were determined. All long-lived cells comprised similar pleiotropic phenotype regarding mitochondrial dynamics and functions. Thus, this study suggests that DSS1, PPA2, and AFG3 genes modulate the lifespan by altering the mitochondrial morphology and functions.

Source

Gene

Volume

706

URI

https://doi.org/10.1016/j.gene.2019.05.001
https://hdl.handle.net/11147/9582

Collections

  • Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik [366]
  • PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection [498]
  • Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection [4673]
  • WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection [4803]



DSpace software copyright © 2002-2015  DuraSpace
Contact Us | Send Feedback
Theme by 
@mire NV
 

 




| Policy | Guide | Contact |

DSpace@IZTECH

by OpenAIRE
Advanced Search

sherpa/romeo

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsTypeLanguageDepartmentCategoryPublisherAccess TypeInstitution AuthorThis CollectionBy Issue DateAuthorsTitlesSubjectsTypeLanguageDepartmentCategoryPublisherAccess TypeInstitution Author

My Account

LoginRegister

Statistics

View Google Analytics Statistics

DSpace software copyright © 2002-2015  DuraSpace
Contact Us | Send Feedback
Theme by 
@mire NV
 

 


| Policy | | Guide | Library | idealdspace University | OAI-PMH |

IYTE, İzmir, Turkey
If you find any errors in content, please contact:

Creative Commons License
idealdspace University Institutional Repository is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 Unported License..

DSpace@IZTECH is member of:



DSpace Release 6.2