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dc.contributor.authorOzenler, Sezer
dc.contributor.authorYucel, Muge
dc.contributor.authorTuncel, Ozge
dc.contributor.authorKaya, Hakan
dc.contributor.authorOzcelik, Serdar
dc.contributor.authorYildiz, Umit Hakan
dc.date.accessioned2020-07-25T22:16:55Z
dc.date.available2020-07-25T22:16:55Z
dc.date.issued2019
dc.identifier.issn0003-2700
dc.identifier.issn1520-6882
dc.identifier.urihttps://doi.org/10.1021/acs.analchem.9b02300
dc.identifier.urihttps://hdl.handle.net/11147/9555
dc.descriptionKAYA, Hakan/0000-0001-9739-9676; ozenler, sezer/0000-0001-6045-7035; Ozcelik, Serdar/0000-0003-2029-0108; Tuncel, Ozge/0000-0002-0873-133Xen_US
dc.descriptionWOS: 000482545300003en_US
dc.descriptionPubMed: 31334629en_US
dc.description.abstractThis letter describes formation of single chain cationic polymer dots (Pdots) made of poly[1,4-dimethy1-1-(34(2,4,5-trimethylthiophen-3-yl)oxy)propyl)piperazin-1-ium bromide] conjugated polyelectrolyte (CPE). The single chain Pdot formation relies on a simple process which is a rapid nanophase separation between CPE solution of ethylene glycol and water. Pdots show narrow monodisperse size distribution with a 3.6 nm in diameter exhibiting high brightness and excellent colloidal and optical stability. It has been demonstrated that photoluminescent Pdots provide selective nuclear translocation to hepatocellular carcinoma cells as compared to healthy liver cells. The Pdot labeling effectively discriminates cancer cells in the coculture media. Pdots hold great promise as a luminescent probe to diagnose cancer cells in histology and may guide surgeons during operations to precisely separate out cancerous tissue due to augmented fluorescence brightness.en_US
dc.language.isoengen_US
dc.publisherAmer Chemical Socen_US
dc.relation.isversionof10.1021/acs.analchem.9b02300en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleSingle Chain Cationic Polymer Dot as a Fluorescent Probe for Cell Imaging and Selective Determination of Hepatocellular Carcinoma Cellsen_US
dc.typearticleen_US
dc.relation.journalAnalytical Chemistryen_US
dc.contributor.departmentIzmir Institute of Technologyen_US
dc.identifier.volume91en_US
dc.identifier.issue16en_US
dc.identifier.startpage10357en_US
dc.identifier.endpage10360en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.cont.department-temp[Ozenler, Sezer; Tuncel, Ozge; Ozcelik, Serdar; Yildiz, Umit Hakan] Izmir Inst Technol, Dept Chem, TR-35430 Izmir, Turkey; [Yucel, Muge; Kaya, Hakan] Izmir Inst Technol, Dept Bioengn, TR-35430 Izmir, Turkey; [Ozcelik, Serdar; Yildiz, Umit Hakan] Izmir Inst Technol, Dept Photon, TR-35430 Izmir, Turkey; [Ozcelik, Serdar] Stanford Univ, Sch Med, Dept Radiat Oncol, Palo Alto, CA 94305 USAen_US


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