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dc.contributor.authorKeman, Deniz
dc.contributor.authorSoyer, Ferda
dc.date.accessioned2020-07-25T22:16:53Z
dc.date.available2020-07-25T22:16:53Z
dc.date.issued2019
dc.identifier.issn2470-1343
dc.identifier.urihttps://doi.org/10.1021/acsomega.9b01336
dc.identifier.urihttps://hdl.handle.net/11147/9537
dc.descriptionSoyer, Ferda/0000-0001-8307-1258en_US
dc.descriptionWOS: 000488852700008en_US
dc.descriptionPubMed: 31572838en_US
dc.description.abstractDevelopment of resistance to antibiotics is one of the major reasons of difficulties in treatments of diseases caused by antibiotic-resistant bacteria, and this resistance makes the investigation of alternative antimicrobials a key priority. Phenolic acids are plant- and fungi-originating natural antimicrobial products, and there is no known bacterial resistance after exposure to them. The purpose of this study was to investigate the resistance ability of bacteria against phenolic acids. Therefore, the ability of methicillin-resistant Staphylococcus aureus and methicillin-susceptible S. aureus to gain resistance against two phenolic acids and an antibiotic upon exposure to subinhibitory concentrations was tested. Herein, we evaluated the minimum inhibitory concentrations (MICs) of vanillic acid (VA), 2-hydroxycinnamic acid (2-HCA), and vancomycin in the beginning of the experiment and the MICs were found to be 2.5 mg/mL VA, 1.6 mg/mL 2-HCA, and 0.01 mg/mL vancomycin for both bacteria. Following continuous treatments with increasing subinhibitory concentrations, MICs were evaluated once more. Exposure to subinhibitory concentrations of vancomycin induced the development of resistance immediately; however, resistance to both phenolic acids could not be induced. These data indicated the potential of phenolic acids to be used as effective antimicrobials in the inhibition of antibiotic-resistant pathogenic bacteria.en_US
dc.language.isoengen_US
dc.publisherAmer Chemical Socen_US
dc.relation.isversionof10.1021/acsomega.9b01336en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleAntibiotic-Resistant Staphylococcus aureus Does Not Develop Resistance to Vanillic Acid and 2-Hydroxycinnamic Acid after Continuous Exposure in Vitroen_US
dc.typearticleen_US
dc.relation.journalAcs Omegaen_US
dc.contributor.departmentIzmir Institute of Technologyen_US
dc.identifier.volume4en_US
dc.identifier.issue13en_US
dc.identifier.startpage15393en_US
dc.identifier.endpage15400en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.cont.department-temp[Keman, Deniz; Soyer, Ferda] Izmir Inst Technol, Dept Mol Biol & Genet, TR-35430 Izmir, Turkeyen_US


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