The role of cysteine cathepsins in cancer progression and drug resistance
Soond, Surinder M.
Vinarov, Andrey Z.
Korolev, Dmitry O.
Morozov, Andrey O.
Zamyatnin, Andrey A.
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Cysteine cathepsins are lysosomal enzymes belonging to the papain family. Their expression is misregulated in a wide variety of tumors, and ample data prove their involvement in cancer progression, angiogenesis, metastasis, and in the occurrence of drug resistance. However, while their overexpression is usually associated with highly aggressive tumor phenotypes, their mechanistic role in cancer progression is still to be determined to develop new therapeutic strategies. In this review, we highlight the literature related to the role of the cysteine cathepsins in cancer biology, with particular emphasis on their input into tumor biology.
SourceInternational Journal of Molecular Sciences
- Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik 
- PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection 
- Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection 
- WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection