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dc.contributor.authorInan, Hakan
dc.contributor.authorKingsley, James L.
dc.contributor.authorOzen, Mehmet O.
dc.contributor.authorTekin, Huseyin Cumhur
dc.contributor.authorHoerner, Christian R.
dc.contributor.authorImae, Yoriko
dc.contributor.authorDemirci, Utkan
dc.descriptionTuzel, Erkan/0000-0002-1337-9932; Hoerner, Christian/0000-0002-8685-1126en_US
dc.descriptionWOS: 000410937000006en_US
dc.descriptionPubMed: 30740513en_US
dc.description.abstractNeutrophils have a critical role in regulating the immune system. The immune system is compromised during chemotherapy, increasing infection risks and imposing a need for regular monitoring of neutrophil counts. Although commercial hematology analyzers are currently used in clinical practice for neutrophil counts, they are only available in clinics and hospitals, use large blood volumes, and are not available at the point of care (POC). Additionally, phlebotomy and blood processing require trained personnel, where patients are often admitted to hospitals when the infections are at late stage due to lack of frequent monitoring. Here, a reliable method is presented that selectively captures and quantifies white blood cells (WBCs) and neutrophils from a finger prick volume of whole blood by integrating microfluidics with high-resolution imaging algorithms. The platform is compact, portable, and easy to use. It captures and quantifies WBCs and neutrophils with high efficiency (> 95%) and specificity (> 95%) with an overall 4.2% bias compared to standard testing. The results from a small cohort of patients (N = 11 healthy, N = 5 lung and kidney cancer) present a unique disposable cell counter, demonstrating the ability of this tool to monitor neutrophil and WBC counts within clinical or in resource-constrained environments.en_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.subjectcancer monitoringen_US
dc.subjectlens-free shadow imagingen_US
dc.subjectPoisson distributionen_US
dc.titleMonitoring Neutropenia for Cancer Patients at the Point of Careen_US
dc.relation.journalSmall Methodsen_US
dc.contributor.departmentIzmir Institute of Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.cont.department-temp[Inan, Hakan; Ozen, Mehmet O.; Demirci, Utkan] Stanford Univ, Canary Ctr Stanford Canc Early Detect, Demirci Bioacoust MEMS Med BAMM Lab, Sch Med,Dept Radiol, 3155 Porter Dr, Palo Alto, CA 94304 USA; [Kingsley, James L.; Tuzel, Erkan] Worcester Polytech Inst, Dept Phys, 100 Inst Rd, Worcester, MA 01609 USA; [Tekin, Huseyin Cumhur] Izmir Inst Technol, Dept Bioengn, TR-35100 Izmir, Turkey; [Hoerner, Christian R.; Wakelee, Heather; Fan, Alice C.] Stanford Univ, Sch Med, Dept Med, Div Oncol, Stanford, CA 94305 USA; [Imae, Yoriko; Metzner, Thomas J.; Preiss, Jordan S.; Wakelee, Heather; Fan, Alice C.] Stanford Canc Inst, Stanford, CA 94305 USA; [Durmus, Naside Gozde] Stanford Univ, Dept Biochem, Stanford, CA 94305 USA; [Ozsoz, Mehmet] 6500-1 Sokak,8F, TR-35100 Karsiyaka Izmir, Turkey; [Demirci, Utkan] Stanford Univ, Dept Elect Engn, Stanford, CA 94305 USAen_US

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