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dc.contributor.authorTamburaci, Sedef
dc.contributor.authorKimna, Ceren
dc.contributor.authorTihminlioglu, Funda
dc.date.accessioned2020-07-25T22:07:33Z
dc.date.available2020-07-25T22:07:33Z
dc.date.issued2018
dc.identifier.issn0883-9115
dc.identifier.issn1530-8030
dc.identifier.urihttps://doi.org/10.1177/0883911518793913
dc.identifier.urihttps://hdl.handle.net/11147/9168
dc.descriptionKIMNA, CEREN/0000-0003-2283-4295en_US
dc.descriptionWOS: 000450365400005en_US
dc.description.abstractMedicinal plants are attracting considerable interest as a potential therapeutic agent for bone tissue regeneration. Cissus quadrangularis L. is also a medicinal plant known with its osteogenic activity. In this study, a phytochemical scaffold was produced by incorporating Cissus quadrangularis with chitosan/Na-carboxymethyl cellulose blend by lyophilization technique. The effect of Cissus quadrangularis loading on the mechanical, morphological, chemical, and degradation properties as well as in vitro cytotoxicity, cell proliferation, and differentiation of the composites was investigated. Scanning electron microscopy images showed that porous Cissus quadrangularis-loaded scaffolds were obtained with an average pore size of 148-209 mu m which is appropriate for bone regeneration. Cissus quadrangularis incorporation enhanced the compression modulus of scaffolds from 76 to 654 kPa. In vitro cell culture results indicated that Cissus quadrangularis/chitosan/Na-carboxymethyl cellulose scaffolds provided a favorable substrate for the osteoblast adhesion, proliferation, and mineralization. Results supported the osteoinductive property of the Cissus quadrangularis extract-incorporated scaffolds even without osteogenic media supplement. Cissus quadrangularis extract increased the alkaline phosphatase activity of the SaOS-2 cells on scaffolds on 7th and 14th days of incubation. The investigation of characterization and cell culture studies suggest that Cissus quadrangularis-loaded osteoinductive Cissus quadrangularis/chitosan/Na-carboxymethyl cellulose scaffold can serve as a potential biomaterial for bone tissue engineering applications.en_US
dc.language.isoengen_US
dc.publisherSage Publications Ltden_US
dc.relation.isversionof10.1177/0883911518793913en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCissus quadrangularisen_US
dc.subjectscaffolden_US
dc.subjectboneen_US
dc.subjectchitosanen_US
dc.subjectNa-carboxymethyl celluloseen_US
dc.titleNovel phytochemical Cissus quadrangularis extract-loaded chitosan/Na-carboxymethyl cellulose-based scaffolds for bone regenerationen_US
dc.typearticleen_US
dc.relation.journalJournal Of Bioactive And Compatible Polymersen_US
dc.contributor.departmentIzmir Institute of Technologyen_US
dc.identifier.volume33en_US
dc.identifier.issue6en_US
dc.identifier.startpage629en_US
dc.identifier.endpage646en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.cont.department-temp[Tamburaci, Sedef] Izmir Inst Technol, Biotechnol & Bioengn Grad Program, Izmir, Turkey; [Tamburaci, Sedef; Kimna, Ceren; Tihminlioglu, Funda] Izmir Inst Technol, Dept Chem Engn, Gulbahce Campus, TR-35430 Izmir, Turkeyen_US


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