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dc.contributor.authorDağlıoğlu, Cenk
dc.contributor.authorKacı, Fatma Necmiye
dc.date.accessioned2020-07-25T22:03:22Z
dc.date.available2020-07-25T22:03:22Z
dc.date.issued2019-04
dc.identifier.issn0378-5173
dc.identifier.issn1873-3476
dc.identifier.urihttps://doi.org/10.1016/j.ijpharm.2019.02.036
dc.identifier.urihttps://hdl.handle.net/11147/9059
dc.descriptionPubMed: 30825555en_US
dc.description.abstractChemotherapy frequently involves combination treatment protocols to maximize tumor cell killing. Unfortunately these intensive chemotherapeutic regimes, often show disappointing results due to the development of drug resistance and higher nonspecific toxicity on normal tissues. In cancer treatment, it is critically important to minimize toxicity while preserving efficacy. We have previously addressed this issue and proposed a nanoparticle-based combination therapy involving both a molecularly targeted therapy and chemotherapeutic agent for neutralizing antiapoptotic survivin (BIRC5) to potentiate the efficacy of doxorubicin (DOX). Although the particles exhibited strong anticancer effect on the lung carcinoma A549 and the cervical carcinoma HeLa cells, there were lower-level therapeutic outcomes on the colon carcinoma HCT-116, the leukemia Jurkat and the pancreatic carcinoma MIA PaCa-2 cells. Since targeted therapies are one of the key approaches for overcoming drug resistance, tailoring the treatment of cancer cells with distinct characteristics is necessary to improve the therapeutic outcome of cancer therapy and to minimize potential pharmacokinetic interactions of drugs. In the light of this issue, this study examined whether a cascade therapy with low-dose DOX and survivin-targeted tailored nanoparticles is more effective at sensitizing HCT-116, Jurkat and MIA PaCa-2 cancer cells to DOX-chemotherapy than simultaneous combination therapy. The results demonstrated that the sequential therapy with the protocol comprising addition of the nanoparticles after incubation of cells with DOX clearly advanced the therapeutic outcome of related cancer cells, whereas the reverse protocol resulted in a reduction or delay in apoptosis, emphasizing the critical importance of formulating synergistic drug combinations in cancer therapy.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.ijpharm.2019.02.036en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNanoparticlesen_US
dc.subjectChemoresistanceen_US
dc.subjectDoxorubicinen_US
dc.subjectSurvivinen_US
dc.subjectColon canceren_US
dc.subjectPancreatic canceren_US
dc.subjectLeukemiaen_US
dc.titleCascade therapy with doxorubicin and survivin-targeted tailored nanoparticles: An effective alternative for sensitization of cancer cells to chemotherapyen_US
dc.typearticleen_US
dc.contributor.institutionauthorDağlıoğlu, Cenk
dc.relation.journalInternational Journal of Pharmaceuticsen_US
dc.contributor.departmentIzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume561en_US
dc.identifier.startpage74en_US
dc.identifier.endpage81en_US
dc.identifier.wosWOS:000462468700008
dc.identifier.scopusSCOPUS:2-s2.0-85062166189
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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