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Characterization of the BETA1 gene, which might play a role in Beta vulgaris subsp. Maritima salt tolerance
(TÜBİTAK, 2017)
Salinity stress has a negative impact on plant growth, which affects homeostasis and productivity. The uptake of nonessential salt ions changes the osmotic balance of the cell and causes dehydration. Higher plants develop ...
Proteomic changes during boron tolerance in barley (Hordeum vulgare) and the role of vacuolar proton-translocating ATPase subunit E
(TÜBİTAK, 2011)
Boron is an essential micronutrient for plants and animals; however, it can be toxic when present at high concentrations. The purpose of this study was to understand the mechanisms of boron tolerance in the Turkish barley ...
Functional analysis of free methionine-R-sulfoxide reductase from saccharomyces cerevisiae
(American Society for Biochemistry and Molecular Biology, 2009-02)
Methionine sulfoxide reductases (Msrs) are oxidoreductases that catalyze thiol-dependent reduction of oxidized methionines. MsrA and MsrB are the best known Msrs that repair methionine S-sulfoxide (Met-S-SO) and ...
Evidence for the presence of a second electron donor for the cytoplasmic thioredoxins in the yeast Saccharomyces cerevisiae
(TÜBİTAK, 2006)
In yeast, the cytoplasmic thioredoxin system is composed of NADPH, thioredoxin reductase-1 (TRR1) and 2 thioredoxin genes (TRX1, TRX2). In this study, using yeast knockout mutants for TRR1, TRX1 and TRX2 genes, the role ...
Identification of a novel system for boron transport: Atr1 is a main boron exporter in yeast
(American Society for Microbiology, 2009-07)
Boron is a micronutrient in plants and animals, but its specific roles in cellular processes are not known. To understand boron transport and functions, we screened a yeast genomic DNA library for genes that confer resistance ...
Functional characterization of new mutations in Wilson disease gene (ATP7B) using the yeast model
(Elsevier, 2015-07)
The Wilson disease gene, a copper transporting ATPase (Atp7b), is responsible for the sequestration of Cu into secretory vesicles, and this function is exhibited by the orthologous Ccc2p in the yeast. In this study, we ...
Thiol peroxidase deficiency leads to increased mutational load and decreased fitness in saccharomyces cerevisiae
(Genetics Society of America, 2014-11)
Thiol peroxidases are critical enzymes in the redox control of cellular processes that function by reducing low levels of hydroperoxides and regulating redox signaling. These proteins were also shown to regulate genome ...
High-copy overexpression screening reveals PDR5 as the main doxorubicin resistance gene in yeast
(Public Library of Science, 2015-12)
Doxorubicin is one of the most potent anticancer drugs used in the treatment of various cancer types. The efficacy of doxorubicin is influenced by the drug resistance mechanisms and its cytotoxicity. In this study, we ...