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Polyethers isolated from the marine actinobacterium Streptomyces cacaoi inhibit autophagy and induce apoptosis in cancer cells

Khan, Nasar; Yılmaz, Sinem; Aksoy, Semiha; Uzel, Ataç; Tosun, Çiğdem; Kırmızıbayrak, Petek Ballar; Bedir, Erdal (Elsevier, 2019-07)

Polyether compounds, a large group of biologically active metabolites produced by Streptomyces species have been reported to show a variety of bioactivity such as antibacterial, antifungal, antiparasitic, antiviral, and ...

Synergistic apoptotic effects of bortezomib and methylstat on multiple myeloma cells

Kacı, Fatma Necmiye; Kiraz, Yağmur; Çekdemir, Demet; Baran, Yusuf (Elsevier, 2020-04)

Background. In this study, we aimed to determine synergistic apoptotic and cytotoxic effects of methylstat and bortezomib on U266 and ARH77 multiple myeloma (MM) cells. Methods. Cytotoxic effects of the drugs were demonstrated ...