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Use of microRNAs in personalized medicine
(Springer, 2014)
Personalized medicine comprises the genetic information together with the phenotypic and environmental factors to yield healthcare tailored to an individual and removes the limitations of the "one-size-fits-all" therapy ...
Step-by-step quantitative analysis of focal adhesions
(Elsevier, 2014)
Focal adhesions (FAs) are specialized adhesive structures which serve as cellular communication units between cells and the surrounding extracellular matrix. FAs are involved in signal transduction and actin cytoskeleton ...
1.55 Å-resolution structure of ent-copalyl diphosphate synthase and exploration of general acid function by site-directed mutagenesis
(Elsevier, 2014)
Background The diterpene cyclase ent-copalyl diphosphate synthase (CPS) catalyzes the first committed step in the biosynthesis of gibberellins. The previously reported 2.25 Å resolution crystal structure of CPS complexed ...
Absence of superoxide dismutase activity causes nuclear DNA fragmentation during the aging process
(Elsevier, 2014-02)
Superoxide dismutases (SOD) serve as an important antioxidant defense mechanism in aerobic organisms, and deletion of these genes shortens the replicative life span in the budding yeast Saccharomyces cerevisiae. Even though ...
Gene reporter assay to validate microRNA targets in drosophila S2 cells
(Humana Press, 2014)
Bioinformatics programs have helped tremendously in identifying the targets of microRNAs, which are small noncoding RNAs that regulate gene expression posttranscriptionally. However, the partial complementarity between ...
Apoptotic effects of quercitrin on DLD-1 colon cancer cell line
(Springer, 2014-08)
Quercetin, which is the most abundant bioflavonoid compound, is mainly present in the glycoside form of quercitrin. Although different studies indicated that quercitrin is a potent antioxidant, the action of this compound ...
Serine carboxypeptidase SCPEP1 and cathepsin a play complementary roles in regulation of vasoconstriction via inactivation of endothelin-1
(Public Library of Science, 2014-02)
The potent vasoconstrictor peptides, endothelin 1 (ET-1) and angiotensin II control adaptation of blood vessels to fluctuations of blood pressure. Previously we have shown that the circulating level of ET-1 is regulated ...
Therapeutic potential of apigenin, a plant flavonoid, for imatinib-sensitive and resistant chronic myeloid leukemia cells
(Routledge, 2014-05)
Despite the presence of many therapeutic regimens like imatinib and other tyrosine kinase inhibitors, the development of resistance, intolerance, and side effects makes chronic myeloid leukemia (CML) therapy challenging. ...
Computational prediction of MicroRNAs from toxoplasma gondii potentially regulating the hosts' gene expression
(Elsevier, 2014-10)
MicroRNAs (miRNAs) were discovered two decades ago, yet there is still a great need for further studies elucidating their genesis and targeting in different phyla. Since experimental discovery and validation of miRNAs is ...
Characterization of a cDNA from Beta maritima that confers nickel tolerance in yeast
(Elsevier, 2014-04)
Nickel is an essential micronutrient due to its involvement in many enzymatic reactions as a cofactor. However, excess of this element is toxic to biological systems. Here, we constructed a cDNA library from Beta maritima ...
