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Characterization of the BETA1 gene, which might play a role in Beta vulgaris subsp. Maritima salt tolerance 

Uysal, Özge; Çakıroğlu, Çiğdem; Koç, Ahmet; Karakaya, Hüseyin Çağlar (TÜBİTAK, 2017)
Salinity stress has a negative impact on plant growth, which affects homeostasis and productivity. The uptake of nonessential salt ions changes the osmotic balance of the cell and causes dehydration. Higher plants develop ...
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Characterization of two genes encoding metal tolerance proteins from Beta vulgaris subspecies maritima that confers manganese tolerance in yeast 

Erbaşol, Işıl; Bozdağ, Gönensin Ozan; Koç, Ahmet; Pedas, Pia; Karakaya, Hüseyin Çağlar (Springer, 2013)
Manganese (Mn2+) is an essential micronutrient in plants. However increased Mn2+ levels are toxic to plant cells. Metal tolerance proteins (MTPs), member of cation diffusion facilitator protein (CDF) family, have important ...
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Absence of superoxide dismutase activity causes nuclear DNA fragmentation during the aging process 

Muid, Khandaker Ashfaqul; Karakaya, Hüseyin Çaǧlar; Koç, Ahmet (Elsevier, 2014-02)
Superoxide dismutases (SOD) serve as an important antioxidant defense mechanism in aerobic organisms, and deletion of these genes shortens the replicative life span in the budding yeast Saccharomyces cerevisiae. Even though ...
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Characterization of long living yeast deletion mutants that lack mitochondrial metabolism genes DSS1, PPA2 and AFG3 

Muid, Khandaker Ashfaqul; Kimyon, Önder; Reza, Shahadat Hasan; Karakaya, Hüseyin Çağlar; Koç, Ahmet (Elsevier, 2019-07)
Molecular mechanisms of aging and longevity are still mostly unknown. Mitochondria play central roles in cellular metabolism and aging. In this study, we identified three deletion mutants of mitochondrial metabolism genes ...
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Genomewide elucidation of drug resistance mechanisms for systemically used antifungal drugs amphotericin B, caspofungin, and voriconazole in the budding yeast 

Balkan, Çiğdem; Ercan, İlkcan; Işık, Esin; Akdeniz, Esra Şahin; Balcıoğlu, Orhan; Kodedova, Marie; Zimmermannova, Olga; Dündar, Muhammed; Sychrova, Hana; Koç, Ahmet (American Society for Microbiology, 2019)
There are only a few antifungal drugs used systemically in treatment, and invasive fungal infections that are resistant to these drugs are an emerging problem in health care. In this study, we performed a high-copy-number ...
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Proteomic changes during boron tolerance in barley (Hordeum vulgare) and the role of vacuolar proton-translocating ATPase subunit E 

Atik, Ahmet Emin; Bozdağ, Gönensin Ozan; Akıncı, Ersin; Kaya, Alaattin; Koç, Ahmet; Yalçın, Talat; Karakaya, Hüseyin Çağlar (TÜBİTAK, 2011)
Boron is an essential micronutrient for plants and animals; however, it can be toxic when present at high concentrations. The purpose of this study was to understand the mechanisms of boron tolerance in the Turkish barley ...
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Identification of respiratory chain gene mutations that shorten replicative life span in yeast 

Hacıoğlu, Elise; Demir, Ayşe Banu; Koç, Ahmet (Elsevier, 2012-02)
Aging is the progressive accumulation of alterations in cells that elevates the risk of death. The mitochondrial theory of aging postulates that free radicals produced by the mitochondrial respiratory system contribute to ...
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Compartmentalization and regulation of mitochondrial function by methionine sulfoxide reductases in yeast 

Kaya, Alaattin; Koç, Ahmet; Lee, Byung Cheon; Fomenko, Dmitri E.; Rederstorff, Mathieu; Krol, Alain; Lescure, Alain; Gladyshev, Vadim N. (American Chemical Society, 2010-10)
Elevated levels of reactive oxygen species can damage proteins. Sulfur-containing amino acid residues, cysteine and methionine, are particularly susceptible to such damage. Various enzymes evolved to protect proteins or ...
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Characterization of a cDNA from Beta maritima that confers nickel tolerance in yeast 

Bozdaǧ, Gönensin Ozan; Kaya, Alaattin; Koç, Ahmet; Noll, Gundula A.; Prüfer, Dirk; Karakaya, Hüseyin Çaǧlar (Elsevier, 2014-04)
Nickel is an essential micronutrient due to its involvement in many enzymatic reactions as a cofactor. However, excess of this element is toxic to biological systems. Here, we constructed a cDNA library from Beta maritima ...
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Thiol peroxidase deficiency leads to increased mutational load and decreased fitness in saccharomyces cerevisiae 

Kaya, Alaattin; Lobanov, Alexey V.; Gerashchenko, Maxim V.; Koren, Amnon; Fomenko, Dmitri E.; Koç, Ahmet; Gladyshev, Vadim N. (Genetics Society of America, 2014-11)
Thiol peroxidases are critical enzymes in the redox control of cellular processes that function by reducing low levels of hydroperoxides and regulating redox signaling. These proteins were also shown to regulate genome ...
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Koç, Ahmet (17)
Karakaya, Hüseyin Çağlar (7)Kaya, Alaattin (6)Fomenko, Dmitri E. (4)Gladyshev, Vadim N. (4)Bozdağ, Gönensin Ozan (3)Demir, Ayşe Banu (3)Uluışık, İrem (3)Hacıoğlu, Elise (2)Karakaya, Hüseyin Çaǧlar (2)... View MoreSubjectYeast (8)Saccharomyces cerevisiae (5)Aging (4)Mitochondria (4)Boron (3)Antioxidant (2)Boric acid (2)Chronological aging (2)Genomic DNA (2)Genomics (2)... View MorePublication Type
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Languageeng (17)Publication CategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı (15)Makale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı (2)Access Typeinfo:eu-repo/semantics/openAccess (16)info:eu-repo/semantics/closedAccess (1)Date Issued2011 (4)2010 (3)2014 (3)2015 (2)2019 (2)2012 (1)2013 (1)2017 (1)Full TextYes (17)

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