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Targeting FoxM1 transcription factor in T-cell acute lymphoblastic leukemia cell line
(Elsevier, 2015-03)
The Forkhead box protein M1 (FoxM1) is an important transcription factor having significant roles in various cellular events. FoxM1 overexpression has been reported to be related with many types of cancer. However, it is ...
Nilotinib does not alter the secretory functions of carotid artery endothelial cells in a prothrombotic or antithrombotic fashion
(SAGE Publications, 2015-10)
Background: There have been concerns about the possible prothrombotic effects of nilotinib, especially in patients having cardiovascular risk factors. The potential mechanism behind the increased risk of thromboembolic ...
Apoptotic effects of resveratrol, a grape polyphenol, on imatinib-sensitive and resistant K562 chronic myeloid leukemia cells
(International Institute of Anticancer Research, 2012-07)
To examine the antiproliferative and apoptotic effects of resveratrol on imatinib-sensitive and imatinib-resistant K562 chronic myeloid leukemia cells. Antiproliferative effects of resveratrol were determined by the ...
Resveratrol and quercetin-induced apoptosis of human 232B4 chronic lymphocytic leukemia cells by activation of caspase-3 and cell cycle arrest
(Taylor & Francis, 2013)
Chronic lymphocytic leukemia (CLL), defined by accumulation of pathogenic B cells, has a very complex biology due to various factors such as inherited, host, and enviromental factors. Recently, finding new therapeutic ...
Quercetin-induced apoptosis involves increased hTERT enzyme activity of leukemic cells
(Taylor & Francis, 2011-09)
We aimed to examine the growth suppressive effects of quercetin on acute promyelocytic and lymphoblastic leukemia and chronic myeloid leukemia, and to find out whether the growth suppression is related to the blocking of ...
Apoptotic effects of non-edible parts of Punica granatum on human multiple myeloma cells
(Springer, 2016-02)
Multiple myeloma is of great concern since existing therapies are unable to cure this clinical condition. Alternative therapeutic approaches are mandatory, and the use of plant extracts is considered interesting. Punica ...
Imatinib induces autophagy through BECLIN-1 and ATG5 genes in chronic myeloid leukemia cells
(Taylor & Francis, 2011-03)
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Hematology
Volume 16, Issue 2, March 2011, Pages 95-99
Imatinib induces autophagy ...
A molecular and biophysical comparison of macromolecular changes in imatinib-sensitive and imatinib-resistant K562 cells exposed to ponatinib
(Springer, 2016-02)
Chronic myeloid leukemia (CML) is a type of hematological malignancy that is characterized by the generation of Philadelphia chromosome encoding BCR/ABL oncoprotein. Tyrosine kinase inhibitors (TKIs), imatinib, nilotinib, ...
A novel mechanism of dasatinib-induced apoptosis in chronic myeloid leukemia; Ceramide synthase and ceramide clearance genes
(Springer, 2011-11)
Sphingolipids are bioeffector molecules that control various aspects of cell growth, proliferation, apoptosis, and drug resistance. Ceramides, the central molecule of sphingolipid metabolism, are inducer of apoptosis and ...
The roles of bioactive sphingolipids in resveratrol-induced apoptosis in HL60 acute myeloid leukemia cells
(Springer-Verlag, 2011-02)
Purpose Acute promyelocytic leukemia results from a translocation between 15 and 17 chromosomes that produce PML/RARa fusion protein. PML/RARa inhibits differentiation of myeloid precursor cells at stem cell level. Resveratrol ...
