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Mice Doubly-deficient in lysosomal hexosaminidase a and neuraminidase 4 show epileptic crises and rapid neuronal loss
(Public Library of Science, 2010-09)
Tay-Sachs disease is a severe lysosomal disorder caused by mutations in the HexA gene coding for the a-subunit of lysosomal β-hexosaminidase A, which converts GM2 to GM3 ganglioside. Hexa-/- mice, depleted of b-hexosaminidase ...
Sur1-Trpm4 cation channel expression in human cerebral infarcts
(Oxford University Press, 2015-08)
The nonselective monovalent cation channel transient receptor potential melastatin 4 (Trpm4) is transcriptionally upregulated in neural and vascular cells in animal models of brain infarction. It associates with sulfonylurea ...
Boron stress activates the general amino acid control mechanism and inhibits protein synthesis
(Public Library of Science, 2011-11)
Boron is an essential micronutrient for plants, and it is beneficial for animals. However, at high concentrations boron is toxic to cells although the mechanism of this toxicity is not known. Atr1 has recently been identified ...
The impact of feature selection on one and two-class classification performance for plant microRNAs
(PeerJ Inc., 2016)
MicroRNAs (miRNAs) are short nucleotide sequences that form a typical hairpin structure which is recognized by a complex enzyme machinery. It ultimately leads to the incorporation of 18-24 nt long mature miRNAs into RISC ...
Therapeutic effects of AICAR and DOX conjugated multifunctional nanoparticles in sensitization and elimination of cancer cells via survivin targeting
(Springer, 2017-01)
Purpose: Resistance to chemotherapy is one of the major problems facing current cancer research. Enhancing tumor cell response to anticancer agents increases chemotherapeutic effectiveness. We have recently addressed this ...
Prevalence of hepatitis B viral infection in Punjab province of Pakistan
(University of Punjab, 2017-08)
Hepatitis B viral (HBV) infection is a major health problem globally and more prevalent in Pakistan, and HBV. which is the main etiological agent of chronic hepatitis B, hepatocellular carcinoma and liver cirrhosis. A total ...
Synthesis and characterization of AICAR and DOX conjugated multifunctional nanoparticles as a platform for synergistic inhibition of cancer cell growth
(American Chemical Society, 2016-04-20)
The success of cancer treatment depends on the response to chemotherapeutic agents. However, malignancies often acquire resistance to drugs if they are used frequently. Combination therapy involving both a chemotherapeutic ...
Revealing genome-wide mRNA and microRNA expression patterns in leukemic cells highlighted “hsa-miR-2278” as a tumor suppressor for regain of chemotherapeutic imatinib response due to targeting STAT5A
(Springer, 2015-09)
BCR-ABL oncoprotein stimulates cell proliferation and inhibits apoptosis in chronic myeloid leukemia (CML). For cure, imatinib is a widely used tyrosine kinase inhibitor, but developing chemotherapeutic resistance has to ...
Morphological and molecular diversity in Turkish sesame germplasm and core set selection
(Crop Science Society of America, 2015)
The conservation of plant germplasm is essential to ensure future breeding gains and crop bio-diversity. To be truly useful, such germplasm must be characterized for morphological traits and genetic diversity. In this work, ...
Intraperitoneal mesenchymal stem cell administration ameliorates allergic rhinitis in the murine model
(Springer, 2017-01)
Previous studies showed that bone marrow-derived mesenchymal stem cells (BMSCs) could ameliorate a variety of immune-mediated and inflammatory diseases due to their immunomodulatory and anti-inflammatory effects. In this ...
